{"metadata":{"accession":"IPR033471","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"smart":{"SM01135":"DIRP"},"pfam":{"PF06584":"DIRP"}},"integrated":null,"hierarchy":{"accession":"IPR033471","name":"DIRP domain","type":"Domain","children":[]},"name":{"name":"DIRP domain","short":"DIRP"},"description":[{"text":"<p>DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway [[cite:PUB00019415]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019415":{"PMID":11076766,"ISBN":null,"volume":"127","issue":"24","year":2000,"title":"Transcription of meiotic cell cycle and terminal differentiation genes depends on a conserved chromatin associated protein, whose nuclear localisation is regulated.","URL":null,"raw_pages":"5463-73","medline_journal":"Development","ISO_journal":"Development","authors":["White-Cooper H","Leroy D","MacQueen A","Fuller MT."],"DOI_URL":"http://dev.biologists.org/cgi/content/abstract/127/24/5463"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":64,"interactions":0,"matches":4175,"pathways":10,"proteins":4172,"proteomes":1643,"sets":0,"structural_models":{"alphafold":3664,"bfvd":0},"structures":2,"taxa":5458},"entry_annotations":{"alignment:seed":36,"alignment:full":2578},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}