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{
    "metadata": {
        "accession": "IPR033471",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "smart": {
                "SM01135": "DIRP"
            },
            "pfam": {
                "PF06584": "DIRP"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR033471",
            "name": "DIRP domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "DIRP domain",
            "short": "DIRP"
        },
        "description": [
            {
                "text": "<p>DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway [[cite:PUB00019415]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00019415": {
                "PMID": 11076766,
                "ISBN": null,
                "volume": "127",
                "issue": "24",
                "year": 2000,
                "title": "Transcription of meiotic cell cycle and terminal differentiation genes depends on a conserved chromatin associated protein, whose nuclear localisation is regulated.",
                "URL": null,
                "raw_pages": "5463-73",
                "medline_journal": "Development",
                "ISO_journal": "Development",
                "authors": [
                    "White-Cooper H",
                    "Leroy D",
                    "MacQueen A",
                    "Fuller MT."
                ],
                "DOI_URL": "http://dev.biologists.org/cgi/content/abstract/127/24/5463"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 64,
            "interactions": 0,
            "matches": 4175,
            "pathways": 10,
            "proteins": 4172,
            "proteomes": 1643,
            "sets": 0,
            "structural_models": {
                "alphafold": 3664,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 5458
        },
        "entry_annotations": {
            "alignment:seed": 36,
            "alignment:full": 2578
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}