"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR028747"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 612, 'pathways': 3, 'proteins': 612, 'proteomes': 294, 'sets': 0, 'structural_models': {'alphafold': 527, 'bfvd': 0}, 'structures': 1, 'taxa': 1125}"	"{}"	"[{'text': '<p>CATSPER  (cationic channel of sperm) is a complex ion channel that mediates Ca2+ entry in sperm flagellum and is required for sperm hyperactivation and male fertility [[cite:PUB00069143]]. The CATSPER channel consists of four CatSper proteins (CatSper1-4) that form a tetramer surrounding a Ca(2+)-selective pore.  In addition to the pore-forming proteins, the CATSPER channel contains auxiliary subunits [[cite:PUB00067741]].</p>\r\n<p>All four CatSper proteins are predicted to contain a common coiled-coil protein-protein interaction domain in their C-terminal tail [[cite:PUB00069136]] and all four are required for male fertility and sperm cell hyperactivated motility [[cite:PUB00069144]]. The CatSper channel of human sperm is activated by progesterone [[cite:PUB00069145]].</p>', 'llm': False, 'checked': False, 'updated': False}, {'text': '<p>This entry represents cation channel sperm-associated protein 2 (CatSper2) [[cite:PUB00069159]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	"[{'identifier': 'GO:0005227', 'name': 'calcium-activated cation channel activity', 'category': {'code': 'F', 'name': 'molecular_function'}}, {'identifier': 'GO:0030317', 'name': 'flagellated sperm motility', 'category': {'code': 'P', 'name': 'biological_process'}}, {'identifier': 'GO:0036128', 'name': 'CatSper complex', 'category': {'code': 'C', 'name': 'cellular_component'}}]"	"{'accession': 'IPR028747', 'name': 'Cation channel sperm-associated protein 2', 'type': 'Family', 'children': []}"	""	False	False	False	"{'PUB00069159': {'PMID': 12825070, 'ISBN': None, 'volume': '11', 'issue': '7', 'year': 2003, 'title': 'CATSPER2, a human autosomal nonsyndromic male infertility gene.', 'URL': None, 'raw_pages': '497-502', 'medline_journal': 'Eur J Hum Genet', 'ISO_journal': 'Eur. J. Hum. Genet.', 'authors': ['Avidan N', 'Tamary H', 'Dgany O', 'Cattan D', 'Pariente A', 'Thulliez M', 'Borot N', 'Moati L', 'Barthelme A', 'Shalmon L', 'Krasnov T', 'Ben-Asher E', 'Olender T', 'Khen M', 'Yaniv I', 'Zaizov R', 'Shalev H', 'Delaunay J', 'Fellous M', 'Lancet D', 'Beckmann JS.'], 'DOI_URL': 'http://dx.doi.org/10.1038/sj.ejhg.5200991'}, 'PUB00069136': {'PMID': 12932298, 'ISBN': None, 'volume': '1', 'issue': None, 'year': 2003, 'title': 'Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.', 'URL': None, 'raw_pages': '53', 'medline_journal': 'Reprod Biol Endocrinol', 'ISO_journal': 'Reprod. Biol. Endocrinol.', 'authors': ['Lobley A', 'Pierron V', 'Reynolds L', 'Allen L', 'Michalovich D.'], 'DOI_URL': 'http://dx.doi.org/10.1186/1477-7827-1-53'}, 'PUB00067741': {'PMID': 21224844, 'ISBN': None, 'volume': '2', 'issue': None, 'year': 2011, 'title': 'A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.', 'URL': None, 'raw_pages': '153', 'medline_journal': 'Nat Commun', 'ISO_journal': 'Nat Commun', 'authors': ['Chung JJ', 'Navarro B', 'Krapivinsky G', 'Krapivinsky L', 'Clapham DE.'], 'DOI_URL': 'http://dx.doi.org/10.1038/ncomms1153'}, 'PUB00069143': {'PMID': 11595941, 'ISBN': None, 'volume': '413', 'issue': '6856', 'year': 2001, 'title': 'A sperm ion channel required for sperm motility and male fertility.', 'URL': None, 'raw_pages': '603-9', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Ren D', 'Navarro B', 'Perez G', 'Jackson AC', 'Hsu S', 'Shi Q', 'Tilly JL', 'Clapham DE.'], 'DOI_URL': 'http://dx.doi.org/10.1038/35098027'}, 'PUB00069144': {'PMID': 17227845, 'ISBN': None, 'volume': '104', 'issue': '4', 'year': 2007, 'title': 'All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.', 'URL': None, 'raw_pages': '1219-23', 'medline_journal': 'Proc Natl Acad Sci U S A', 'ISO_journal': 'Proc. Natl. Acad. Sci. U.S.A.', 'authors': ['Qi H', 'Moran MM', 'Navarro B', 'Chong JA', 'Krapivinsky G', 'Krapivinsky L', 'Kirichok Y', 'Ramsey IS', 'Quill TA', 'Clapham DE.'], 'DOI_URL': 'http://dx.doi.org/10.1073/pnas.0610286104'}, 'PUB00069145': {'PMID': 21412339, 'ISBN': None, 'volume': '471', 'issue': '7338', 'year': 2011, 'title': 'Progesterone activates the principal Ca2+ channel of human sperm.', 'URL': None, 'raw_pages': '387-91', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Lishko PV', 'Botchkina IL', 'Kirichok Y.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nature09767'}}"	"{'panther': {'PTHR46923': 'CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2'}}"	"{'name': 'Cation channel sperm-associated protein 2', 'short': 'CatSper2'}"	""	""	""	"interpro"	"family"	""