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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR028747",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0005227",
"name": "calcium-activated cation channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0030317",
"name": "flagellated sperm motility",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0036128",
"name": "CatSper complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR46923": "CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR028747",
"name": "Cation channel sperm-associated protein 2",
"type": "Family",
"children": []
},
"name": {
"name": "Cation channel sperm-associated protein 2",
"short": "CatSper2"
},
"description": [
{
"text": "<p>CATSPER (cationic channel of sperm) is a complex ion channel that mediates Ca2+ entry in sperm flagellum and is required for sperm hyperactivation and male fertility [[cite:PUB00069143]]. The CATSPER channel consists of four CatSper proteins (CatSper1-4) that form a tetramer surrounding a Ca(2+)-selective pore. In addition to the pore-forming proteins, the CATSPER channel contains auxiliary subunits [[cite:PUB00067741]].</p>\r\n<p>All four CatSper proteins are predicted to contain a common coiled-coil protein-protein interaction domain in their C-terminal tail [[cite:PUB00069136]] and all four are required for male fertility and sperm cell hyperactivated motility [[cite:PUB00069144]]. The CatSper channel of human sperm is activated by progesterone [[cite:PUB00069145]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents cation channel sperm-associated protein 2 (CatSper2) [[cite:PUB00069159]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00069159": {
"PMID": 12825070,
"ISBN": null,
"volume": "11",
"issue": "7",
"year": 2003,
"title": "CATSPER2, a human autosomal nonsyndromic male infertility gene.",
"URL": null,
"raw_pages": "497-502",
"medline_journal": "Eur J Hum Genet",
"ISO_journal": "Eur. J. Hum. Genet.",
"authors": [
"Avidan N",
"Tamary H",
"Dgany O",
"Cattan D",
"Pariente A",
"Thulliez M",
"Borot N",
"Moati L",
"Barthelme A",
"Shalmon L",
"Krasnov T",
"Ben-Asher E",
"Olender T",
"Khen M",
"Yaniv I",
"Zaizov R",
"Shalev H",
"Delaunay J",
"Fellous M",
"Lancet D",
"Beckmann JS."
],
"DOI_URL": "http://dx.doi.org/10.1038/sj.ejhg.5200991"
},
"PUB00069136": {
"PMID": 12932298,
"ISBN": null,
"volume": "1",
"issue": null,
"year": 2003,
"title": "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.",
"URL": null,
"raw_pages": "53",
"medline_journal": "Reprod Biol Endocrinol",
"ISO_journal": "Reprod. Biol. Endocrinol.",
"authors": [
"Lobley A",
"Pierron V",
"Reynolds L",
"Allen L",
"Michalovich D."
],
"DOI_URL": "http://dx.doi.org/10.1186/1477-7827-1-53"
},
"PUB00067741": {
"PMID": 21224844,
"ISBN": null,
"volume": "2",
"issue": null,
"year": 2011,
"title": "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"URL": null,
"raw_pages": "153",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Chung JJ",
"Navarro B",
"Krapivinsky G",
"Krapivinsky L",
"Clapham DE."
],
"DOI_URL": "http://dx.doi.org/10.1038/ncomms1153"
},
"PUB00069143": {
"PMID": 11595941,
"ISBN": null,
"volume": "413",
"issue": "6856",
"year": 2001,
"title": "A sperm ion channel required for sperm motility and male fertility.",
"URL": null,
"raw_pages": "603-9",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Ren D",
"Navarro B",
"Perez G",
"Jackson AC",
"Hsu S",
"Shi Q",
"Tilly JL",
"Clapham DE."
],
"DOI_URL": "http://dx.doi.org/10.1038/35098027"
},
"PUB00069144": {
"PMID": 17227845,
"ISBN": null,
"volume": "104",
"issue": "4",
"year": 2007,
"title": "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.",
"URL": null,
"raw_pages": "1219-23",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Qi H",
"Moran MM",
"Navarro B",
"Chong JA",
"Krapivinsky G",
"Krapivinsky L",
"Kirichok Y",
"Ramsey IS",
"Quill TA",
"Clapham DE."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.0610286104"
},
"PUB00069145": {
"PMID": 21412339,
"ISBN": null,
"volume": "471",
"issue": "7338",
"year": 2011,
"title": "Progesterone activates the principal Ca2+ channel of human sperm.",
"URL": null,
"raw_pages": "387-91",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Lishko PV",
"Botchkina IL",
"Kirichok Y."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature09767"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 612,
"pathways": 3,
"proteins": 612,
"proteomes": 294,
"sets": 0,
"structural_models": {
"alphafold": 527,
"bfvd": 0
},
"structures": 1,
"taxa": 1125
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
