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InterPro-Version: 108.0
InterPro-Version-Minor: 0
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{
"metadata": {
"accession": "IPR028319",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0008134",
"name": "transcription factor binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006915",
"name": "apoptotic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0045786",
"name": "negative regulation of cell cycle",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd17224": "Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR048942",
"name": "Apoptosis-stimulating of p53 protein 2-like, RA domain",
"type": "Domain",
"children": [
{
"accession": "IPR028319",
"name": "Apoptosis-stimulating of p53 protein 1, RA domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047166",
"name": "Apoptosis-stimulating protein of p53 protein 2, RA domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Apoptosis-stimulating of p53 protein 1, RA domain",
"short": "ASPP1_RA"
},
"description": [
{
"text": "<p>ASPP1 (apoptosis-stimulating of p53 protein) is a member of the ASPP protein family (Apoptosi-Stimulating Protein of p53) that activates the p53-mediated apoptotic response. It functions as a tumour suppressor and coordinates with p53 to protect haematopoietic stem cell (HSC) pool integrity, guarding against haematological malignancies [[cite:PUB00101744], [cite:PUB00101745], [cite:PUB00067973]]. The ASPP family of proteins may be a target for cancer therapy [[cite:PUB00067976]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the RA domain present at the N terminus of ASSP1, which is a ubiquitin-like domain.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00067976": {
"PMID": 17211478,
"ISBN": null,
"volume": "96",
"issue": "2",
"year": 2007,
"title": "ASPP: a new family of oncogenes and tumour suppressor genes.",
"URL": null,
"raw_pages": "196-200",
"medline_journal": "Br J Cancer",
"ISO_journal": "Br. J. Cancer",
"authors": [
"Sullivan A",
"Lu X."
],
"DOI_URL": "http://dx.doi.org/10.1038/sj.bjc.6603525"
},
"PUB00067973": {
"PMID": 11684014,
"ISBN": null,
"volume": "8",
"issue": "4",
"year": 2001,
"title": "ASPP proteins specifically stimulate the apoptotic function of p53.",
"URL": null,
"raw_pages": "781-94",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Samuels-Lev Y",
"O'Connor DJ",
"Bergamaschi D",
"Trigiante G",
"Hsieh JK",
"Zhong S",
"Campargue I",
"Naumovski L",
"Crook T",
"Lu X."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1097-2765(01)00367-7"
},
"PUB00101745": {
"PMID": 26119234,
"ISBN": null,
"volume": "17",
"issue": "1",
"year": 2015,
"title": "Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.",
"URL": null,
"raw_pages": "23-34",
"medline_journal": "Cell Stem Cell",
"ISO_journal": "Cell Stem Cell",
"authors": [
"Yamashita M",
"Nitta E",
"Suda T."
],
"DOI_URL": null
},
"PUB00101744": {
"PMID": 25660448,
"ISBN": null,
"volume": "458",
"issue": "3",
"year": 2015,
"title": "The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly.",
"URL": null,
"raw_pages": "494-500",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem Biophys Res Commun",
"authors": [
"Zhang Y",
"Wang Y",
"Wei Y",
"Ma J",
"Peng J",
"Wumaier R",
"Shen S",
"Zhang P",
"Yu L."
],
"DOI_URL": null
},
"PUB00067974": {
"PMID": 14729977,
"ISBN": null,
"volume": "24",
"issue": "3",
"year": 2004,
"title": "ASPP1 and ASPP2: common activators of p53 family members.",
"URL": null,
"raw_pages": "1341-50",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Bergamaschi D",
"Samuels Y",
"Jin B",
"Duraisingham S",
"Crook T",
"Lu X."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.24.3.1341-1350.2004"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR029071",
"name": "Ubiquitin-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 775,
"pathways": 6,
"proteins": 775,
"proteomes": 362,
"sets": 0,
"structural_models": {
"alphafold": 691,
"bfvd": 0
},
"structures": 0,
"taxa": 1219
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
