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{
    "metadata": {
        "accession": "IPR028245",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR31962": "SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"
            },
            "pfam": {
                "PF13805": "Eisosome component PIL1"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR028245",
            "name": "Eisosome component PIL1/LSP1",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Eisosome component PIL1/LSP1",
            "short": "PIL1/LSP1"
        },
        "description": [
            {
                "text": "<p>In the budding yeast, S. cerevisiae, Pil1 and another cytoplasmic protein, Lsp1, together form large immobile assemblies at the plasma membrane that mark sites for endocytosis, called eisosomes [[cite:PUB00067737], [cite:PUB00045143]].  Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalise nutrients in all eukaryotic cells.</p>",
                "llm": false,
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                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00045143": {
                "PMID": 16496001,
                "ISBN": null,
                "volume": "439",
                "issue": "7079",
                "year": 2006,
                "title": "Eisosomes mark static sites of endocytosis.",
                "URL": null,
                "raw_pages": "998-1003",
                "medline_journal": "Nature",
                "ISO_journal": "Nature",
                "authors": [
                    "Walther TC",
                    "Brickner JH",
                    "Aguilar PS",
                    "Bernales S",
                    "Pantoja C",
                    "Walter P."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nature04472"
            },
            "PUB00067737": {
                "PMID": 21900489,
                "ISBN": null,
                "volume": "22",
                "issue": "21",
                "year": 2011,
                "title": "The filament-forming protein Pil1 assembles linear eisosomes in fission yeast.",
                "URL": null,
                "raw_pages": "4059-67",
                "medline_journal": "Mol Biol Cell",
                "ISO_journal": "Mol. Biol. Cell",
                "authors": [
                    "Kabeche R",
                    "Baldissard S",
                    "Hammond J",
                    "Howard L",
                    "Moseley JB."
                ],
                "DOI_URL": "http://dx.doi.org/10.1091/mbc.E11-07-0605"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR027267",
                "name": "AH/BAR domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 51,
            "interactions": 0,
            "matches": 3762,
            "pathways": 0,
            "proteins": 3741,
            "proteomes": 1428,
            "sets": 0,
            "structural_models": {
                "alphafold": 3243,
                "bfvd": 0
            },
            "structures": 9,
            "taxa": 3216
        },
        "entry_annotations": {
            "alignment:seed": 21,
            "alignment:full": 2491
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}