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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR026971",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0007076",
"name": "mitotic chromosome condensation",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR14222": "CONDENSIN"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR026971",
"name": "Condensin subunit 1/Condensin-2 complex subunit D3",
"type": "Family",
"children": [
{
"accession": "IPR007673",
"name": "Condensin subunit 1",
"type": "Family",
"children": []
},
{
"accession": "IPR012371",
"name": "Condensin-2 complex subunit D3",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Condensin subunit 1/Condensin-2 complex subunit D3",
"short": "CND1/NCAPD3"
},
"description": [
{
"text": "<p>This entry includes condensin subunit 1 (CND1) and condensin-2 complex subunit D3 (NCAPD3).</p>\n\n<p>CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes [[cite:PUB00007177]]. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [[cite:PUB00062096], [cite:PUB00010072], [cite:PUB00062097], [cite:PUB00100765]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00062096": {
"PMID": 11854418,
"ISBN": null,
"volume": "13",
"issue": "2",
"year": 2002,
"title": "Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior.",
"URL": null,
"raw_pages": "632-45",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol. Biol. Cell",
"authors": [
"Bhalla N",
"Biggins S",
"Murray AW."
],
"DOI_URL": "http://dx.doi.org/10.1091/mbc.01-05-0264"
},
"PUB00010072": {
"PMID": 9774278,
"ISBN": null,
"volume": "282",
"issue": "5388",
"year": 1998,
"title": "Phosphorylation and activation of 13S condensin by Cdc2 in vitro.",
"URL": null,
"raw_pages": "487-90",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Kimura K",
"Hirano M",
"Kobayashi R",
"Hirano T."
],
"DOI_URL": "http://dx.doi.org/10.1126/science.282.5388.487"
},
"PUB00062097": {
"PMID": 11136719,
"ISBN": null,
"volume": "276",
"issue": "8",
"year": 2001,
"title": "Chromosome condensation by a human condensin complex in Xenopus egg extracts.",
"URL": null,
"raw_pages": "5417-20",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Kimura K",
"Cuvier O",
"Hirano T."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.C000873200"
},
"PUB00056240": {
"PMID": 14532007,
"ISBN": null,
"volume": "115",
"issue": "1",
"year": 2003,
"title": "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.",
"URL": null,
"raw_pages": "109-21",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Ono T",
"Losada A",
"Hirano M",
"Myers MP",
"Neuwald AF",
"Hirano T."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(03)00724-4"
},
"PUB00007177": {
"PMID": 12138188,
"ISBN": null,
"volume": "22",
"issue": "16",
"year": 2002,
"title": "Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7.",
"URL": null,
"raw_pages": "5769-81",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Ball AR Jr",
"Schmiesing JA",
"Zhou C",
"Gregson HC",
"Okada Y",
"Doi T",
"Yokomori K."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.22.16.5769-5781.2002"
},
"PUB00100765": {
"PMID": 27737959,
"ISBN": null,
"volume": "30",
"issue": "19",
"year": 2016,
"title": "Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.",
"URL": null,
"raw_pages": "2158-2172",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Martin CA",
"Murray JE",
"Carroll P",
"Leitch A",
"Mackenzie KJ",
"Halachev M",
"Fetit AE",
"Keith C",
"Bicknell LS",
"Fluteau A",
"Gautier P",
"Hall EA",
"Joss S",
"Soares G",
"Silva J",
"Bober MB",
"Duker A",
"Wise CA",
"Quigley AJ",
"Phadke SR; Deciphering Developmental Disorders Study",
"Wood AJ",
"Vagnarelli P",
"Jackson AP."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR016024",
"name": "Armadillo-type fold",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 8474,
"pathways": 7,
"proteins": 8474,
"proteomes": 3307,
"sets": 0,
"structural_models": {
"alphafold": 3831,
"bfvd": 0
},
"structures": 8,
"taxa": 9349
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
