{"metadata":{"accession":"IPR025743","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF14331":"IcmF-related N-terminal domain"}},"integrated":null,"hierarchy":{"accession":"IPR025743","name":"Type VI secretion system component TssM1, N-terminal domain","type":"Domain","children":[]},"name":{"name":"Type VI secretion system component TssM1, N-terminal domain","short":"TssM1_N"},"description":[{"text":"<p>This domain is found at the N-terminal of the Type VI secretion component TssM1 from Pseudomonas aeruginosa, which plays a role in the release of toxins targeting both eukaryotic and prokaryotic species, plays an essential role in stabilization of assembled TssK1 structure at a fixed perimembrane site [[cite:PUB00093973]] and forms part of the tip complex [[cite:PUB00151684]]. This domain is also found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins  [[cite:PUB00012816]] and is usually found N-terminal to [interpro:IPR009612].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00012816":{"PMID":12127983,"ISBN":null,"volume":"295","issue":"4","year":2002,"title":"Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency.","URL":null,"raw_pages":"922-8","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Das S","Chakrabortty A","Banerjee R","Chaudhuri K."],"DOI_URL":"http://dx.doi.org/10.1016/S0006-291X(02)00782-9"},"PUB00151684":{"PMID":26200339,"ISBN":null,"volume":"523","issue":"7562","year":2015,"title":"Biogenesis and structure of a type VI secretion membrane core complex.","URL":null,"raw_pages":"555-60","medline_journal":"Nature","ISO_journal":"Nature","authors":["Durand E","Nguyen VS","Zoued A","Logger L","Pehau-Arnaudet G","Aschtgen MS","Spinelli S","Desmyter A","Bardiaux B","Dujeancourt A","Roussel A","Cambillau C","Cascales E","Fronzes R."],"DOI_URL":null},"PUB00093973":{"PMID":31379775,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.","URL":null,"raw_pages":"1615","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Liebl D","Robert-Genthon M","Job V","Cogoni V","Attree I."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":4412,"pathways":0,"proteins":4404,"proteomes":3053,"sets":0,"structural_models":{"alphafold":2204},"structures":0,"taxa":4391},"entry_annotations":{"alignment:seed":84,"alignment:full":1563},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}