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{
    "metadata": {
        "accession": "IPR024639",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF12213": "DNA polymerases epsilon N terminal"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR024639",
            "name": "DNA polymerase epsilon subunit B, N-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "DNA polymerase epsilon subunit B, N-terminal",
            "short": "DNA_pol_e_bsu_N"
        },
        "description": [
            {
                "text": "<p>This domain is found in the N-terminal of DNA polymerase epsilon subunit B proteins. It contains a single completely conserved phenylalanine residue that may be functionally important. It forms a primarily α helical structure in which four helices are arranged in two hairpins with connecting loops containing β strands which form a short parallel sheet.</p>\r\n\r\n<p>DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. The N-terminal domain has close structural relation to AAA+ protein C-terminal domains [[cite:PUB00049604]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00049604": {
                "PMID": 18676977,
                "ISBN": null,
                "volume": "36",
                "issue": "15",
                "year": 2008,
                "title": "The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins.",
                "URL": null,
                "raw_pages": "5102-10",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "Nuutinen T",
                    "Tossavainen H",
                    "Fredriksson K",
                    "Pirila P",
                    "Permi P",
                    "Pospiech H",
                    "Syvaoja JE."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/nar/gkn497"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 26,
            "interactions": 0,
            "matches": 1841,
            "pathways": 44,
            "proteins": 1841,
            "proteomes": 1126,
            "sets": 0,
            "structural_models": {
                "alphafold": 1696,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 4013
        },
        "entry_annotations": {
            "alignment:seed": 6,
            "alignment:full": 1245
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}