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{
    "metadata": {
        "accession": "IPR024178",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003707",
                "name": "nuclear steroid receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005496",
                "name": "steroid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008270",
                "name": "zinc ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pirsf": {
                "PIRSF002527": "Estrogen receptor-like nuclear receptor"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR001723",
            "name": "Nuclear hormone receptor",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR000003",
                    "name": "Retinoid X receptor/HNF4",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR000128",
                    "name": "Progesterone receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR000324",
                    "name": "Vitamin D receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR001409",
                    "name": "Glucocorticoid receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR001728",
                    "name": "Thyroid hormone receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR003069",
                    "name": "Ecdysteroid receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR003070",
                    "name": "Orphan nuclear receptor",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR003071",
                            "name": "Orphan nuclear receptor, HMR type",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003072",
                            "name": "Orphan nuclear receptor, NOR1 type",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003073",
                            "name": "Orphan nuclear receptor, NURR type",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR003074",
                    "name": "Peroxisome proliferator-activated receptor",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR003075",
                            "name": "Peroxisome proliferator-activated receptor, beta",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003076",
                            "name": "Peroxisome proliferator-activated receptor alpha",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003077",
                            "name": "Peroxisome proliferator-activated receptor gamma",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR003078",
                    "name": "Retinoic acid receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR003079",
                    "name": "Nuclear receptor ROR",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR016355",
                    "name": "Nuclear hormone receptor family 5",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR023257",
                    "name": "Liver X receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR024178",
                    "name": "Estrogen receptor/oestrogen-related receptor",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR001292",
                            "name": "Estrogen receptor",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR027289",
                            "name": "Oestrogen-related receptor",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR028355",
                            "name": "Estrogen receptor beta/gamma",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR033544",
                    "name": "Nuclear receptor subfamily 0 group B member 1/2",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "Estrogen receptor/oestrogen-related receptor",
            "short": "Est_rcpt/est-rel_rcp"
        },
        "description": [
            "<p>Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands [[cite:PUB00015853]]. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [[cite:PUB00004464], [cite:PUB00006168]]. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.</p>\r\n\r\n<p>NRs are extremely important in medical research, a large number of them being implicated in diseases such as cancer, diabetes, hormone resistance syndromes, etc. While several NRs act as ligand-inducible transcription factors, many do not yet have a defined ligand and are accordingly termed 'orphan' receptors. During the last decade, more than 300 NRs have been described, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.</p>",
            "<p>The oestrogen receptors (ERs) are steroid or nuclear hormone receptors that act as transcription regulators involved in diverse physiological functions. Oestrogen receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. The ER consists of three functional and structural domains: an N-terminal modulatory domain, a highly conserved DNA-binding domain that recognises specific sequences ([interpro:IPR001628]), and a C-terminal ligand-binding domain ([interpro:IPR000536]). </p>",
            "<p>This entry represents oestrogen receptors and oestrogen-related receptors, which are members of the subfamily 3 of nuclear receptors [[cite:PUB00054107]]. Oestrogen-related receptors (ERR-alpha, ERR-beta, and ERR-gamma) are orphan nuclear receptors whose physiological ligands have not yet been identified. Although ERRs are closely related to oestrogen receptors\r\n(ERs) they do not respond to oestrogens [[cite:PUB00055623]].\r\n</p>"
        ],
        "wikipedia": null,
        "literature": {
            "PUB00015853": {
                "PMID": 14747695,
                "ISBN": null,
                "volume": "2004",
                "issue": "217",
                "year": 2004,
                "title": "Nuclear receptors: the evolution of diversity.",
                "URL": null,
                "raw_pages": "pe4",
                "medline_journal": "Sci STKE",
                "ISO_journal": "Sci. STKE",
                "authors": [
                    "Schwabe JW",
                    "Teichmann SA."
                ],
                "DOI_URL": "http://dx.doi.org/10.1126/stke.2172004pe4"
            },
            "PUB00055623": {
                "PMID": 12185669,
                "ISBN": null,
                "volume": "13",
                "issue": "5",
                "year": 2002,
                "title": "To ERR in the estrogen pathway.",
                "URL": null,
                "raw_pages": "220-5",
                "medline_journal": "Trends Endocrinol Metab",
                "ISO_journal": "Trends Endocrinol. Metab.",
                "authors": [
                    "Giguere V."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S1043-2760(02)00592-1"
            },
            "PUB00006168": {
                "PMID": 8165128,
                "ISBN": null,
                "volume": "22",
                "issue": "7",
                "year": 1994,
                "title": "Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
                "URL": null,
                "raw_pages": "1161-6",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "De Vos P",
                    "Schmitt J",
                    "Verhoeven G",
                    "Stunnenberg HG."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/nar/22.7.1161"
            },
            "PUB00054107": {
                "PMID": 10219237,
                "ISBN": null,
                "volume": "97",
                "issue": "2",
                "year": 1999,
                "title": "A unified nomenclature system for the nuclear receptor superfamily.",
                "URL": null,
                "raw_pages": "161-3",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Nuclear Receptors Nomenclature Committee."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(00)80726-6"
            },
            "PUB00004464": {
                "PMID": 7899080,
                "ISBN": null,
                "volume": "23",
                "issue": "4",
                "year": 1995,
                "title": "Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
                "URL": null,
                "raw_pages": "606-11",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "Nishikawa J",
                    "Kitaura M",
                    "Imagawa M",
                    "Nishihara T."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/nar/23.4.606"
            }
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 6324,
            "pathways": 70,
            "proteins": 6015,
            "proteomes": 681,
            "sets": 0,
            "structural_models": {
                "alphafold": 4423,
                "rosettafold": 0
            },
            "structures": 402,
            "taxa": 3085
        },
        "entry_annotations": {},
        "cross_references": {}
    }
}