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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR022692",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0016888",
"name": "DNA endonuclease activity, producing 5'-phosphomonoesters",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF08283": "Geminivirus rep protein central domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR022692",
"name": "Geminivirus AL1 replication-associated protein, central domain",
"type": "Domain",
"children": []
},
"name": {
"name": "Geminivirus AL1 replication-associated protein, central domain",
"short": "Gemini_AL1_REP_central"
},
"description": [
{
"text": "<p>Geminiviruses are characterised by a genome of circular single-stranded DNA encapsidated in twinned (geminate) quasi-isometric particles, from which the group derives its name [[cite:PUB00001145]]. Most geminiviruses can be divided into two subgroups on the basis of host range and/or insect vector: i.e. those that infect dicotyledenous plants and are transmitted by the same whitefly species, and those that infect monocotyledenous plants and are transmitted by different leafhopper vectors. The genomes of the whitefly-transmitted African cassava mosaic virus, Tomato golden mosaic virus (TGMV) and Bean golden mosaic virus (BGMV) possess a bipartite genome. By contrast, only a single DNA component has been identified for the leafhopper-transmitted Maize streak virus (MSV) and Wheat dwarf virus (WDV) [[cite:PUB00001133], [cite:PUB00004348]]. Beet curly top virus (BCTV), and Tobacco yellow dwarf virus belong to a third possible subgroup. Like MSV and WDV, BCTV is transmitted by a specific leafhopper species, yet like the whitefly-transmitted geminiviruses it has a host range confined to dicotyledenous plants.</p>\n\n<p>Sequence comparison of the whitefly-transmitted Squash leaf curl virus (SqLCV) and Tomato yellow leaf curl virus (TYLCV) with the genomic components of TGMV and BGMV reveals a close evolutionary relationship [[cite:PUB00004397], [cite:PUB00005574], [cite:PUB00005578]]. Amino acid sequence alignments of Potato yellow mosaic virus (PYMV) proteins with those encoded by other geminiviruses show that PYMV is closely related to geminiviruses isolated from the New World, especially in the putative coat protein gene regions [[cite:PUB00005578]]. Comparison of MSV DNA-encoded proteins with those of other geminiviruses infecting monocotyledonous plants, including Panicum streak virus [[cite:PUB00003143]] and Miscanthus streak virus (MiSV) [[cite:PUB00003142]], reveal high levels of similarity.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This is the central region of the geminivirus rep proteins [[cite:PUB00017127]]. It is found C-terminal to [pfam:PF00799] and is thought to be responsible for oligomerisation.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00004397": {
"PMID": 1840676,
"ISBN": null,
"volume": "19",
"issue": "24",
"year": 1991,
"title": "Tomato yellow leaf curl virus from Sardinia is a whitefly-transmitted monopartite geminivirus.",
"URL": null,
"raw_pages": "6763-9",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Kheyr-Pour A",
"Bendahmane M",
"Matzeit V",
"Accotto GP",
"Crespi S",
"Gronenborn B."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/19.24.6763"
},
"PUB00001145": {
"PMID": 16453696,
"ISBN": null,
"volume": "5",
"issue": "8",
"year": 1986,
"title": "The nucleotide sequence of an infectious clone of the geminivirus beet curly top virus.",
"URL": null,
"raw_pages": "1761-1767",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Stanley J",
"Markham PG",
"Callis RJ",
"Pinner MS."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=16453696"
},
"PUB00004348": {
"PMID": 2829117,
"ISBN": null,
"volume": "16",
"issue": "1",
"year": 1988,
"title": "Infectivity and complete nucleotide sequence of the genome of a South African isolate of maize streak virus.",
"URL": null,
"raw_pages": "229-49",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Lazarowitz SG."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/16.1.229"
},
"PUB00005574": {
"PMID": 1984668,
"ISBN": null,
"volume": "180",
"issue": "1",
"year": 1991,
"title": "Infectivity and complete nucleotide sequence of the cloned genomic components of a bipartite squash leaf curl geminivirus with a broad host range phenotype.",
"URL": null,
"raw_pages": "58-69",
"medline_journal": "Virology",
"ISO_journal": "Virology",
"authors": [
"Lazarowitz SG",
"Lazdins IB."
],
"DOI_URL": "http://dx.doi.org/10.1016/0042-6822(91)90009-Z"
},
"PUB00005578": {
"PMID": 1926771,
"ISBN": null,
"volume": "185",
"issue": "1",
"year": 1991,
"title": "Tomato yellow leaf curl virus: a whitefly-transmitted geminivirus with a single genomic component.",
"URL": null,
"raw_pages": "151-61",
"medline_journal": "Virology",
"ISO_journal": "Virology",
"authors": [
"Navot N",
"Pichersky E",
"Zeidan M",
"Zamir D",
"Czosnek H."
],
"DOI_URL": "http://dx.doi.org/10.1016/0042-6822(91)90763-2"
},
"PUB00001133": {
"PMID": 6526009,
"ISBN": null,
"volume": "3",
"issue": "13",
"year": 1984,
"title": "The nucleotide sequence of maize streak virus DNA.",
"URL": null,
"raw_pages": "3063-8",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Mullineaux PM",
"Donson J",
"Morris-Krsinich BA",
"Boulton MI",
"Davies JW."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=6526009"
},
"PUB00017127": {
"PMID": 12130667,
"ISBN": null,
"volume": "99",
"issue": "16",
"year": 2002,
"title": "The structure of a replication initiator unites diverse aspects of nucleic acid metabolism.",
"URL": null,
"raw_pages": "10310-5",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Campos-Olivas R",
"Louis JM",
"Clerot D",
"Gronenborn B",
"Gronenborn AM."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.152342699"
},
"PUB00003143": {
"PMID": 1588314,
"ISBN": null,
"volume": "73 ( Pt 5)",
"issue": null,
"year": 1992,
"title": "The nucleotide sequence of an infectious insect-transmissible clone of the geminivirus Panicum streak virus.",
"URL": null,
"raw_pages": "1041-7",
"medline_journal": "J Gen Virol",
"ISO_journal": "J. Gen. Virol.",
"authors": [
"Briddon RW",
"Lunness P",
"Chamberlin LC",
"Pinner MS",
"Brundish H",
"Markham PG."
],
"DOI_URL": null
},
"PUB00003142": {
"PMID": 1919519,
"ISBN": null,
"volume": "72 ( Pt 10)",
"issue": null,
"year": 1991,
"title": "The nucleotide sequence and genome structure of the geminivirus miscanthus streak virus.",
"URL": null,
"raw_pages": "2325-31",
"medline_journal": "J Gen Virol",
"ISO_journal": "J. Gen. Virol.",
"authors": [
"Chatani M",
"Matsumoto Y",
"Mizuta H",
"Ikegami M",
"Boulton MI",
"Davies JW."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 11,
"interactions": 0,
"matches": 9483,
"pathways": 17,
"proteins": 9483,
"proteomes": 672,
"sets": 0,
"structural_models": {
"alphafold": 155,
"bfvd": 34
},
"structures": 0,
"taxa": 2078
},
"entry_annotations": {
"alignment:seed": 5,
"alignment:full": 493
},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.7.-",
"url": "https://enzyme.expasy.org/EC/2.7.7.-"
},
{
"accession": "3.1.21.-",
"url": "https://enzyme.expasy.org/EC/3.1.21.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
