{"metadata":{"accession":"IPR021848","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF11927":"Haem-dependent oxidative N-demethylase, alpha subunit-like"}},"integrated":null,"hierarchy":{"accession":"IPR021848","name":"Haem-dependent oxidative N-demethylase, alpha subunit-like","type":"Family","children":[]},"name":{"name":"Haem-dependent oxidative N-demethylase, alpha subunit-like","short":"HODM_asu-like"},"description":[{"text":"<p>This entry represents a family of proteins predominantly found in fungi and bacteria, including the alpha subunit of an haem-dependent oxidative N-demethylase (HODM) from Pseudomonas mendocina (Pmen_3455, [swissprot:A4XXY9]). This protein, catalytically active, is responsible for haem, oxygen and NADPH-dependent dimethylamine (DMA) binding. It shows an N- and C-terminally extended PAS haem binding domain structurally similar to the to the Aer2 PAS domain, but lacks the core PAS-domain α-helix that forms the Aer2 haem pocket, and displays extended β-strands and a longer loop [[cite:PUB00100877]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100877":{"PMID":27851736,"ISBN":null,"volume":"539","issue":"7630","year":2016,"title":"An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.","URL":null,"raw_pages":"593-597","medline_journal":"Nature","ISO_journal":"Nature","authors":["Ortmayer M","Lafite P","Menon BR","Tralau T","Fisher K","Denkhaus L","Scrutton NS","Rigby SE","Munro AW","Hay S","Leys D."],"DOI_URL":null},"PUB00100878":{"PMID":22622145,"ISBN":null,"volume":"48","issue":"52","year":2012,"title":"Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa.","URL":null,"raw_pages":"6523-5","medline_journal":"Chem Commun (Camb)","ISO_journal":"Chem Commun (Camb)","authors":["Sawai H","Sugimoto H","Shiro Y","Ishikawa H","Mizutani Y","Aono S."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":96,"interactions":0,"matches":7486,"pathways":0,"proteins":7314,"proteomes":2933,"sets":0,"structural_models":{"alphafold":6047,"bfvd":0},"structures":3,"taxa":5737},"entry_annotations":{"alignment:seed":210,"alignment:full":4566},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5lte","name":"Crystal structure of the alpha subunit of heme dependent oxidative N-demethylase (HODM)"}}}