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{
    "metadata": {
        "accession": "IPR021848",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF11927": "Haem-dependent oxidative N-demethylase, alpha subunit-like"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR021848",
            "name": "Haem-dependent oxidative N-demethylase, alpha subunit-like",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Haem-dependent oxidative N-demethylase, alpha subunit-like",
            "short": "HODM_asu-like"
        },
        "description": [
            {
                "text": "<p>This entry represents a family of proteins predominantly found in fungi and bacteria, including the alpha subunit of an haem-dependent oxidative N-demethylase (HODM) from Pseudomonas mendocina (Pmen_3455, [swissprot:A4XXY9]). This protein, catalytically active, is responsible for haem, oxygen and NADPH-dependent dimethylamine (DMA) binding. It shows an N- and C-terminally extended PAS haem binding domain structurally similar to the to the Aer2 PAS domain, but lacks the core PAS-domain α-helix that forms the Aer2 haem pocket, and displays extended β-strands and a longer loop [[cite:PUB00100877]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00100877": {
                "PMID": 27851736,
                "ISBN": null,
                "volume": "539",
                "issue": "7630",
                "year": 2016,
                "title": "An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.",
                "URL": null,
                "raw_pages": "593-597",
                "medline_journal": "Nature",
                "ISO_journal": "Nature",
                "authors": [
                    "Ortmayer M",
                    "Lafite P",
                    "Menon BR",
                    "Tralau T",
                    "Fisher K",
                    "Denkhaus L",
                    "Scrutton NS",
                    "Rigby SE",
                    "Munro AW",
                    "Hay S",
                    "Leys D."
                ],
                "DOI_URL": null
            },
            "PUB00100878": {
                "PMID": 22622145,
                "ISBN": null,
                "volume": "48",
                "issue": "52",
                "year": 2012,
                "title": "Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa.",
                "URL": null,
                "raw_pages": "6523-5",
                "medline_journal": "Chem Commun (Camb)",
                "ISO_journal": "Chem Commun (Camb)",
                "authors": [
                    "Sawai H",
                    "Sugimoto H",
                    "Shiro Y",
                    "Ishikawa H",
                    "Mizutani Y",
                    "Aono S."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 96,
            "interactions": 0,
            "matches": 7486,
            "pathways": 0,
            "proteins": 7314,
            "proteomes": 2933,
            "sets": 0,
            "structural_models": {
                "alphafold": 6047,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 5737
        },
        "entry_annotations": {
            "alignment:seed": 210,
            "alignment:full": 4566
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "5lte",
            "name": "Crystal structure of the alpha subunit of heme dependent oxidative N-demethylase (HODM)"
        }
    }
}