{"metadata":{"accession":"IPR021777","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF11822":"SANT and BTB domain regulator of CSR, BTB domain"}},"integrated":null,"hierarchy":{"accession":"IPR021777","name":"SANT and BTB domain regulator of CSR, BTB domain","type":"Domain","children":[]},"name":{"name":"SANT and BTB domain regulator of CSR, BTB domain","short":"SANBR_BTB"},"description":[{"text":"<p>Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR [[cite:PUB00099259]]. This entry includes proteins predominantly found in animals.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00099259":{"PMID":33831416,"ISBN":null,"volume":"296","issue":null,"year":2021,"title":"The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.","URL":null,"raw_pages":"100625","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Zheng S","Matthews AJ","Rahman N","Herrick-Reynolds K","Sible E","Choi JE","Wishnie A","Ng YK","Rhodes D","Elledge SJ","Vuong BQ."],"DOI_URL":null}},"set_info":null,"overlaps_with":[{"accession":"IPR011333","name":"SKP1/BTB/POZ domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":33,"interactions":0,"matches":1680,"pathways":0,"proteins":1676,"proteomes":904,"sets":0,"structural_models":{"alphafold":1492,"bfvd":0},"structures":0,"taxa":3383},"entry_annotations":{"alignment:seed":7,"alignment:full":1113},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}