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{
    "metadata": {
        "accession": "IPR021777",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF11822": "SANT and BTB domain regulator of CSR, BTB domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR021777",
            "name": "SANT and BTB domain regulator of CSR, BTB domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "SANT and BTB domain regulator of CSR, BTB domain",
            "short": "SANBR_BTB"
        },
        "description": [
            {
                "text": "<p>Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR [[cite:PUB00099259]]. This entry includes proteins predominantly found in animals.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00099259": {
                "PMID": 33831416,
                "ISBN": null,
                "volume": "296",
                "issue": null,
                "year": 2021,
                "title": "The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.",
                "URL": null,
                "raw_pages": "100625",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J Biol Chem",
                "authors": [
                    "Zheng S",
                    "Matthews AJ",
                    "Rahman N",
                    "Herrick-Reynolds K",
                    "Sible E",
                    "Choi JE",
                    "Wishnie A",
                    "Ng YK",
                    "Rhodes D",
                    "Elledge SJ",
                    "Vuong BQ."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR011333",
                "name": "SKP1/BTB/POZ domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 33,
            "interactions": 0,
            "matches": 1680,
            "pathways": 0,
            "proteins": 1676,
            "proteomes": 904,
            "sets": 0,
            "structural_models": {
                "alphafold": 1492,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 3383
        },
        "entry_annotations": {
            "alignment:seed": 7,
            "alignment:full": 1113
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}