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{
    "metadata": {
        "accession": "IPR019333",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF10189": "Integrator complex subunit 3 N-terminal"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR019333",
            "name": "Integrator complex subunit 3, N-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Integrator complex subunit 3, N-terminal",
            "short": "INTS3_N"
        },
        "description": [
            {
                "text": "<p>This entry represents the N-terminal domain of the Integrator complex subunit 3 (Ints3). The Integrator complex is involved in small nuclear RNA (snRNA) U1 and U2 transcription, and in their 3'-box-dependent processing. This complex associates with the C-terminal domain of RNA polymerase II largest subunit and is recruited to the U1 and U2 snRNAs genes [[cite:PUB00045283]].</p>\n\n<p>Ints3 (also known as SOSSA) is also a component of the sensor of single-stranded DNA complex (SOSS), which associates with single-stranded DNA, important for DNA repair and efficient homologous recombination [[cite:PUB00098617]]. This subunit serves as a central adaptor for SOSS complex assembly and stability, and facilitates the accumulation of the complex to the sites of DNA damage. This region acts as a scaffold for SOSSB1 and SOSSC interaction and it is not essential for ssDNA binding [[cite:PUB00098617]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00045283": {
                "PMID": 16239144,
                "ISBN": null,
                "volume": "123",
                "issue": "2",
                "year": 2005,
                "title": "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.",
                "URL": null,
                "raw_pages": "265-76",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Baillat D",
                    "Hakimi MA",
                    "Naar AM",
                    "Shilatifard A",
                    "Cooch N",
                    "Shiekhattar R."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.cell.2005.08.019"
            },
            "PUB00098617": {
                "PMID": 24630995,
                "ISBN": null,
                "volume": "6",
                "issue": "6",
                "year": 2014,
                "title": "Structural basis of SOSS1 complex assembly and recognition of ssDNA.",
                "URL": null,
                "raw_pages": "982-991",
                "medline_journal": "Cell Rep",
                "ISO_journal": "Cell Rep",
                "authors": [
                    "Ren W",
                    "Chen H",
                    "Sun Q",
                    "Tang X",
                    "Lim SC",
                    "Huang J",
                    "Song H."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 71,
            "interactions": 0,
            "matches": 3061,
            "pathways": 5,
            "proteins": 2930,
            "proteomes": 1647,
            "sets": 0,
            "structural_models": {
                "alphafold": 2497,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 5448
        },
        "entry_annotations": {
            "alignment:seed": 24,
            "alignment:full": 2008
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "4owt",
            "name": "Structural basis of SOSS1 complex assembly"
        }
    }
}