{"metadata":{"accession":"IPR017748","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF09867":"TagF N-terminal domain, Type VI secretion system-associated"},"ncbifam":{"TIGR03373":"type VI secretion system-associated protein TagF"},"pirsf":{"PIRSF029287":"Uncharacterised conserved protein, UCP029287 type"}},"integrated":null,"hierarchy":{"accession":"IPR017748","name":"T6S-associated protein TagF","type":"Family","children":[]},"name":{"name":"T6S-associated protein TagF","short":"TagF"},"description":[{"text":"<p>This entry includes the T6S-associated protein, TagF, a post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS), found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in diverse processes including host-cell interactions, biofilm formation and gene regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions. TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1, PpkA, or other Tag proteins. TagF forms a homodimer with nearly identical monomers composed of alpha and beta elements assembled as a three-layer sandwich (α-β-α) [[cite:PUB00086563]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086563":{"PMID":22017253,"ISBN":null,"volume":"82","issue":"5","year":2011,"title":"Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation.","URL":null,"raw_pages":"1277-90","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Silverman JM","Austin LS","Hsu F","Hicks KG","Hood RD","Mougous JD."],"DOI_URL":"https://doi.org/10.1111/j.1365-2958.2011.07889.x"}},"set_info":null,"overlaps_with":[{"accession":"IPR038225","name":"T6S-associated protein TagF superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":3768,"pathways":0,"proteins":3765,"proteomes":1890,"sets":0,"structural_models":{"alphafold":2904,"bfvd":0},"structures":3,"taxa":3332},"entry_annotations":{"alignment:seed":36,"alignment:full":867},"cross_references":{"gp":{"displayName":"Genome Properties","description":"Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.","rank":45,"accessions":[{"accession":"GenProp0735","url":"https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0735"}]}},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}