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{
    "metadata": {
        "accession": "IPR017748",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF09867": "TagF N-terminal domain, Type VI secretion system-associated"
            },
            "ncbifam": {
                "TIGR03373": "type VI secretion system-associated protein TagF"
            },
            "pirsf": {
                "PIRSF029287": "Uncharacterised conserved protein, UCP029287 type"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR017748",
            "name": "T6S-associated protein TagF",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "T6S-associated protein TagF",
            "short": "TagF"
        },
        "description": [
            {
                "text": "<p>This entry includes the T6S-associated protein, TagF, a post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS), found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in diverse processes including host-cell interactions, biofilm formation and gene regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions. TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1, PpkA, or other Tag proteins. TagF forms a homodimer with nearly identical monomers composed of alpha and beta elements assembled as a three-layer sandwich (α-β-α) [[cite:PUB00086563]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00086563": {
                "PMID": 22017253,
                "ISBN": null,
                "volume": "82",
                "issue": "5",
                "year": 2011,
                "title": "Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation.",
                "URL": null,
                "raw_pages": "1277-90",
                "medline_journal": "Mol Microbiol",
                "ISO_journal": "Mol. Microbiol.",
                "authors": [
                    "Silverman JM",
                    "Austin LS",
                    "Hsu F",
                    "Hicks KG",
                    "Hood RD",
                    "Mougous JD."
                ],
                "DOI_URL": "https://doi.org/10.1111/j.1365-2958.2011.07889.x"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR038225",
                "name": "T6S-associated protein TagF superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 11,
            "interactions": 0,
            "matches": 3768,
            "pathways": 0,
            "proteins": 3765,
            "proteomes": 1890,
            "sets": 0,
            "structural_models": {
                "alphafold": 2904,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 3332
        },
        "entry_annotations": {
            "alignment:seed": 36,
            "alignment:full": 867
        },
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp0735",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0735"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}