This domain is found at the C-terminal of small ribosomal subunit protein bS22m (formerly known as mS38; also called COX24 in yeast). The mitochondrial protein bS22m shares sequence homology with bacterial bS22, particularly in the N-terminal region, leading to its renaming to reflect their common evolutionary origin. This domain is also found in the bacterial small ribosomal subunit protein bS22, which occupies a similar position beneath the mRNA channel and interacts with 16S rRNA helix 44 to stabilise the decoding centre [[cite:PUB00163225]]. In some proteins this domain convers the whole length of the protein.
","llm":false,"checked":false,"updated":false},{"text":"bS22m is a component of the mitochondrial ribosome (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including essential transmembrane subunits of the mitochondrial respiratory chain. Mitoribosomes are attached to the mitochondrial inner membrane, and translation products are cotranslationally integrated into the membrane [[cite:PUB00089004], [cite:PUB00098057]]. In mammals, bS22m preferentially stimulates translation initiation of COX1, COX2, and COX3 mRNAs [[cite:PUB00163226]]. In yeast, bS22m is also involved in the splicing of the COX1 mRNA [[cite:PUB00076420]].
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