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{
"metadata": {
"accession": "IPR013177",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF08213": "Mitochondrial mRNA-processing protein COX24, C-terminal"
},
"smart": {
"SM01155": "Mitochondrial domain of unknown function (DUF1713)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR013177",
"name": "Ribosomal protein bS22, C-terminal",
"type": "Domain",
"children": []
},
"name": {
"name": "Ribosomal protein bS22, C-terminal",
"short": "Ribosomal_bS22_C"
},
"description": [
{
"text": "<p>This domain is found at the C-terminal of small ribosomal subunit protein bS22m (formerly known as mS38; also called COX24 in yeast). The mitochondrial protein bS22m shares sequence homology with bacterial bS22, particularly in the N-terminal region, leading to its renaming to reflect their common evolutionary origin. This domain is also found in the bacterial small ribosomal subunit protein bS22, which occupies a similar position beneath the mRNA channel and interacts with 16S rRNA helix 44 to stabilise the decoding centre [[cite:PUB00163225]]. In some proteins this domain convers the whole length of the protein.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>bS22m is a component of the mitochondrial ribosome (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including essential transmembrane subunits of the mitochondrial respiratory chain. Mitoribosomes are attached to the mitochondrial inner membrane, and translation products are cotranslationally integrated into the membrane [[cite:PUB00089004], [cite:PUB00098057]]. In mammals, bS22m preferentially stimulates translation initiation of COX1, COX2, and COX3 mRNAs [[cite:PUB00163226]]. In yeast, bS22m is also involved in the splicing of the COX1 mRNA [[cite:PUB00076420]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00163225": {
"PMID": 37034768,
"ISBN": null,
"volume": null,
"issue": null,
"year": 2023,
"title": "The small mycobacterial ribosomal protein, bS22, modulates aminoglycoside accessibility to its 16S rRNA helix-44 binding site.",
"URL": null,
"raw_pages": "2023.03.31.535098",
"medline_journal": "bioRxiv",
"ISO_journal": "bioRxiv",
"authors": [
"Majumdar S",
"Deep A",
"Sharma MR",
"Canestrari J",
"Stone M",
"Smith C",
"Koripella RK",
"Keshavan P",
"Banavali NK",
"Wade JT",
"Gray TA",
"Derbyshire KM",
"Agrawal RK."
],
"DOI_URL": "https://doi.org/10.1101/2023.03.31.535098"
},
"PUB00076420": {
"PMID": 16339141,
"ISBN": null,
"volume": "281",
"issue": "6",
"year": 2006,
"title": "COX24 codes for a mitochondrial protein required for processing of the COX1 transcript.",
"URL": null,
"raw_pages": "3743-51",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Barros MH",
"Myers AM",
"Van Driesche S",
"Tzagoloff A."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M510778200"
},
"PUB00089004": {
"PMID": 25609543,
"ISBN": null,
"volume": "6",
"issue": null,
"year": 2015,
"title": "Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.",
"URL": null,
"raw_pages": "6019",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Pfeffer S",
"Woellhaf MW",
"Herrmann JM",
"Forster F."
],
"DOI_URL": "https://doi.org/10.1038/ncomms7019"
},
"PUB00098057": {
"PMID": 28154081,
"ISBN": null,
"volume": "355",
"issue": "6324",
"year": 2017,
"title": "The structure of the yeast mitochondrial ribosome.",
"URL": null,
"raw_pages": "528-531",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Desai N",
"Brown A",
"Amunts A",
"Ramakrishnan V."
],
"DOI_URL": null
},
"PUB00163226": {
"PMID": 30968120,
"ISBN": null,
"volume": "47",
"issue": "11",
"year": 2019,
"title": "The mitoribosome-specific protein mS38 is preferentially required for synthesis of cytochrome c oxidase subunits.",
"URL": null,
"raw_pages": "5746-5760",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Mays JN",
"Camacho-Villasana Y",
"Garcia-Villegas R",
"Perez-Martinez X",
"Barrientos A",
"Fontanesi F."
],
"DOI_URL": "https://doi.org/10.1093/nar/gkz266"
},
"PUB00078824": {
"PMID": 17125467,
"ISBN": null,
"volume": "403",
"issue": "1",
"year": 2007,
"title": "Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.",
"URL": null,
"raw_pages": "119-27",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Lim SK",
"Gopalan G."
],
"DOI_URL": "http://dx.doi.org/10.1042/BJ20061272"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 43,
"interactions": 0,
"matches": 6671,
"pathways": 7,
"proteins": 6670,
"proteomes": 5397,
"sets": 0,
"structural_models": {
"alphafold": 5136,
"bfvd": 0
},
"structures": 118,
"taxa": 11352
},
"entry_annotations": {
"alignment:seed": 39,
"alignment:full": 3583
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
