{"metadata":{"accession":"IPR012570","entry_id":null,"type":"family","go_terms":[{"identifier":"GO:0009098","name":"L-leucine biosynthetic process","category":{"code":"P","name":"biological_process"}}],"source_database":"interpro","member_databases":{"pfam":{"PF08054":"Leucine operon leader peptide"}},"integrated":null,"hierarchy":{"accession":"IPR012570","name":"Leucine operon leader peptide","type":"Family","children":[]},"name":{"name":"Leucine operon leader peptide","short":"Leu_leader"},"description":[{"text":"<p>This family consists of the leucine operon leader peptide. The leucine operon is involved in the control of the biosynthesis of leucine. Four adjacent leucine codons within the leucine leader RNA are critically important in transcription attenuation-mediated control of leucine operon expression in bacteria. The leader RNA contains translational start and stop signals, a cluster of four leucine codons and overlapping regions of dyad symmetry that are capable of forming stem-and-loop structures [[cite:PUB00016465]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00016465":{"PMID":3922957,"ISBN":null,"volume":"162","issue":"3","year":1985,"title":"Mutations that convert the four leucine codons of the Salmonella typhimurium leu leader to four threonine codons.","URL":null,"raw_pages":"943-9","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Carter PW","Weiss DL","Weith HL","Calvo JM."],"DOI_URL":"http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=3922957&action=stream&blobtype=pdf"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":468,"pathways":0,"proteins":468,"proteomes":105,"sets":0,"structural_models":{"alphafold":418,"bfvd":0},"structures":0,"taxa":469},"entry_annotations":{"alignment:seed":2,"alignment:full":19},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}