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{
    "metadata": {
        "accession": "IPR011528",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "profile": {
                "PS50965": "NERD domain profile"
            },
            "pfam": {
                "PF08378": "Nuclease-related domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR011528",
            "name": "Nuclease-related domain, NERD",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Nuclease-related domain, NERD",
            "short": "NERD"
        },
        "description": [
            "<p>The nuclease-related domain (NERD) is found in a broad range of bacterial, as well as single archaeal and plant proteins. Most NERD-containing proteins have a single domain, sometimes with additional (predicted) transmembrane helices. In a few instances, proteins containing NERD domains have additional domains (mostly involved in DNA processing), such as the HRDC, the UvrD/REP helicase, the DNA-binding C4 zinc finger, or the serine/threonine and tyrosine protein kinases. In all cases in which a NERD domain is present in multidomain proteins, it is found at the N terminus. The NERD domain is predicted to function in DNA processing, and may have a nuclease function [[cite:PUB00014771]].</p>"
        ],
        "wikipedia": null,
        "literature": {
            "PUB00014771": {
                "PMID": 15055202,
                "ISBN": null,
                "volume": "29",
                "issue": "3",
                "year": 2004,
                "title": "NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1.",
                "URL": null,
                "raw_pages": "106-10",
                "medline_journal": "Trends Biochem Sci",
                "ISO_journal": "Trends Biochem. Sci.",
                "authors": [
                    "Grynberg M",
                    "Godzik A."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.tibs.2004.01.002"
            }
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 151,
            "interactions": 0,
            "matches": 20946,
            "pathways": 0,
            "proteins": 20943,
            "proteomes": 3359,
            "sets": 0,
            "structural_models": {
                "alphafold": 18724,
                "rosettafold": 1
            },
            "structures": 0,
            "taxa": 15203
        },
        "entry_annotations": {
            "alignment:uniprot": 20783,
            "alignment:full": 5270,
            "alignment:seed": 352
        },
        "cross_references": {
            "prositedoc": {
                "displayName": "prositedoc",
                "description": "PROSITE is a database of protein families and domains.",
                "rank": 18,
                "accessions": [
                    {
                        "accession": "PDOC50965",
                        "url": "http://prosite.expasy.org/PDOC50965"
                    }
                ]
            }
        }
    }
}