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{
"metadata": {
"accession": "IPR010144",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF09709": "CRISPR-associated protein (Cas_Csd1)"
},
"ncbifam": {
"TIGR01863": "type I-C CRISPR-associated protein Cas8c/Csd1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR010144",
"name": "CRISPR-associated protein, Csd1-type",
"type": "Family",
"children": []
},
"name": {
"name": "CRISPR-associated protein, Csd1-type",
"short": "CRISPR-assoc_prot_Csd1-typ"
},
"description": [
{
"text": "<p>The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the Csd1 (CRISPR/Cas Subtype DVULG protein 1) family of Cas proteins, which tend to be found near CRISPR repeats of the DVULG subtype of CRISPR/Cas locus. The species range for this subtype, so far, is exclusively bacterial and mesophilic, although CRISPR loci in general are particularly common among archaea and thermophilic bacteria.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00060621": {
"PMID": 21699496,
"ISBN": null,
"volume": "439",
"issue": "1",
"year": 2011,
"title": "Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein.",
"URL": null,
"raw_pages": "85-95",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Howard JA",
"Delmas S",
"Ivancic-Bace I",
"Bolt EL."
],
"DOI_URL": "http://dx.doi.org/10.1042/BJ20110901"
},
"PUB00043288": {
"PMID": 16545108,
"ISBN": null,
"volume": "1",
"issue": null,
"year": 2006,
"title": "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action.",
"URL": null,
"raw_pages": "7",
"medline_journal": "Biol Direct",
"ISO_journal": "Biol. Direct",
"authors": [
"Makarova KS",
"Grishin NV",
"Shabalina SA",
"Wolf YI",
"Koonin EV."
],
"DOI_URL": "http://dx.doi.org/10.1186/1745-6150-1-7"
},
"PUB00043287": {
"PMID": 17379808,
"ISBN": null,
"volume": "315",
"issue": "5819",
"year": 2007,
"title": "CRISPR provides acquired resistance against viruses in prokaryotes.",
"URL": null,
"raw_pages": "1709-12",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Barrangou R",
"Fremaux C",
"Deveau H",
"Richards M",
"Boyaval P",
"Moineau S",
"Romero DA",
"Horvath P."
],
"DOI_URL": "http://dx.doi.org/10.1126/science.1138140"
},
"PUB00043286": {
"PMID": 17442114,
"ISBN": null,
"volume": "8",
"issue": "4",
"year": 2007,
"title": "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.",
"URL": null,
"raw_pages": "R61",
"medline_journal": "Genome Biol",
"ISO_journal": "Genome Biol.",
"authors": [
"Kunin V",
"Sorek R",
"Hugenholtz P."
],
"DOI_URL": "http://dx.doi.org/10.1186/gb-2007-8-4-r61"
},
"PUB00071890": {
"PMID": 24459147,
"ISBN": null,
"volume": "289",
"issue": "10",
"year": 2014,
"title": "A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii.",
"URL": null,
"raw_pages": "7164-77",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Brendel J",
"Stoll B",
"Lange SJ",
"Sharma K",
"Lenz C",
"Stachler AE",
"Maier LK",
"Richter H",
"Nickel L",
"Schmitz RA",
"Randau L",
"Allers T",
"Urlaub H",
"Backofen R",
"Marchfelder A."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M113.508184"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 9,
"interactions": 0,
"matches": 2388,
"pathways": 0,
"proteins": 2359,
"proteomes": 1496,
"sets": 0,
"structural_models": {
"alphafold": 1855,
"bfvd": 0
},
"structures": 12,
"taxa": 3656
},
"entry_annotations": {
"alignment:seed": 78,
"alignment:full": 996
},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0021",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0021"
},
{
"accession": "GenProp0313",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0313"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
