{"metadata":{"accession":"IPR009956","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF07362":"Post-segregation antitoxin CcdA"}},"integrated":null,"hierarchy":{"accession":"IPR009956","name":"Post-segregation antitoxin CcdA","type":"Family","children":[]},"name":{"name":"Post-segregation antitoxin CcdA","short":"Post-segregation_anti-tox_CcdA"},"description":[{"text":"<p>This entry consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein [[cite:PUB00013116]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00013116":{"PMID":10196173,"ISBN":null,"volume":"274","issue":"16","year":1999,"title":"Interactions of CcdB with DNA gyrase. Inactivation of Gyra, poisoning of the gyrase-DNA complex, and the antidote action of CcdA.","URL":null,"raw_pages":"10936-44","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Bahassi EM","O'Dea MH","Allali N","Messens J","Gellert M","Couturier M."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.274.16.10936"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":3384,"pathways":0,"proteins":3384,"proteomes":1698,"sets":0,"structural_models":{"alphafold":2691,"bfvd":0},"structures":7,"taxa":3580},"entry_annotations":{"alignment:seed":39,"alignment:full":942},"cross_references":{"gp":{"displayName":"Genome Properties","description":"Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.","rank":45,"accessions":[{"accession":"GenProp0321","url":"https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0321"}]}},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3hpw","name":"CcdB dimer in complex with one C-terminal CcdA domain"}}}