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{
    "metadata": {
        "accession": "IPR009956",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF07362": "Post-segregation antitoxin CcdA"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR009956",
            "name": "Post-segregation antitoxin CcdA",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Post-segregation antitoxin CcdA",
            "short": "Post-segregation_anti-tox_CcdA"
        },
        "description": [
            {
                "text": "<p>This entry consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein [[cite:PUB00013116]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00013116": {
                "PMID": 10196173,
                "ISBN": null,
                "volume": "274",
                "issue": "16",
                "year": 1999,
                "title": "Interactions of CcdB with DNA gyrase. Inactivation of Gyra, poisoning of the gyrase-DNA complex, and the antidote action of CcdA.",
                "URL": null,
                "raw_pages": "10936-44",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Bahassi EM",
                    "O'Dea MH",
                    "Allali N",
                    "Messens J",
                    "Gellert M",
                    "Couturier M."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.274.16.10936"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 15,
            "interactions": 0,
            "matches": 3384,
            "pathways": 0,
            "proteins": 3384,
            "proteomes": 1698,
            "sets": 0,
            "structural_models": {
                "alphafold": 2691,
                "bfvd": 0
            },
            "structures": 7,
            "taxa": 3580
        },
        "entry_annotations": {
            "alignment:seed": 39,
            "alignment:full": 942
        },
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp0321",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0321"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3hpw",
            "name": "CcdB dimer in complex with one C-terminal CcdA domain"
        }
    }
}