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{
    "metadata": {
        "accession": "IPR006334",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0004357",
                "name": "glutamate-cysteine ligase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006750",
                "name": "glutathione biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR38761": "GLUTAMATE--CYSTEINE LIGASE"
            },
            "hamap": {
                "MF_00578": "Glutamate--cysteine ligase [gshA]"
            },
            "ncbifam": {
                "TIGR01434": "glutamate--cysteine ligase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR006334",
            "name": "Glutamate--cysteine ligase, monofunctional",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Glutamate--cysteine ligase, monofunctional",
            "short": "Glut_cys_ligase"
        },
        "description": [
            {
                "text": "<p>These sequences represent glutamate--cysteine ligase, also known as gamma-glutamylcysteine synthetase, an enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can serve to protect against oxidative damage and participate in biosynthetic or detoxification reactions.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR014746",
                "name": "Glutamine synthetase/guanido kinase, catalytic domain",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 7793,
            "pathways": 3,
            "proteins": 7793,
            "proteomes": 3992,
            "sets": 0,
            "structural_models": {
                "alphafold": 6212,
                "bfvd": 0
            },
            "structures": 7,
            "taxa": 6740
        },
        "entry_annotations": {},
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp1359",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1359"
                    },
                    {
                        "accession": "GenProp0030",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0030"
                    }
                ]
            },
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "6.3.2.2",
                        "url": "https://enzyme.expasy.org/EC/6.3.2.2"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3nzt",
            "name": "2.0 Angstrom Crystal structure of Glutamate--Cysteine Ligase (gshA) ftom Francisella tularensis in Complex with AMP"
        }
    }
}