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{
"metadata": {
"accession": "IPR005667",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0015419",
"name": "ABC-type sulfate transporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:1902358",
"name": "sulfate transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR30406": "SULFATE TRANSPORT SYSTEM PERMEASE PROTEIN"
},
"ncbifam": {
"TIGR00969": "sulfate ABC transporter permease subunit"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR005667",
"name": "Sulphate ABC transporter permease protein 2",
"type": "Family",
"children": [
{
"accession": "IPR011865",
"name": "Sulphate ABC transporter, permease protein CysT",
"type": "Family",
"children": []
},
{
"accession": "IPR011866",
"name": "Sulphate ABC transporter, permease protein CysW",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Sulphate ABC transporter permease protein 2",
"short": "Sulph_transpt2"
},
"description": [
{
"text": "<p>Bacterial binding protein-dependent transport systems [[cite:PUB00000042], [cite:PUB00002368]] are multicomponent systems typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system. The integral inner-membrane proteins translocate the substrate across the membrane. It has been shown [[cite:PUB00001137], [cite:PUB00003865]] that most of these proteins contain a conserved region located about 80 to 100 residues from their C-terminal extremity. This region seems to be located in a cytoplasmic loop between two transmembrane domains [[cite:PUB00003831]]. Apart from the conserved region, the sequence of these proteins is quite divergent, and they have a variable number of transmembrane helices.</p>\r\n\r\n<p>This entry describes a subfamily of both CysT and CysW, paralogous and generally tandemly encoded permease proteins of the sulphate ABC transporter [[cite:PUB00035343], [cite:PUB00035344]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00000042": {
"PMID": 3527048,
"ISBN": null,
"volume": "55",
"issue": null,
"year": 1986,
"title": "Bacterial periplasmic transport systems: structure, mechanism, and evolution.",
"URL": null,
"raw_pages": "397-425",
"medline_journal": "Annu Rev Biochem",
"ISO_journal": "Annu. Rev. Biochem.",
"authors": [
"Ames GF."
],
"DOI_URL": "http://dx.doi.org/10.1146/annurev.bi.55.070186.002145"
},
"PUB00002368": {
"PMID": 2229036,
"ISBN": null,
"volume": "22",
"issue": "4",
"year": 1990,
"title": "Binding protein-dependent transport systems.",
"URL": null,
"raw_pages": "571-92",
"medline_journal": "J Bioenerg Biomembr",
"ISO_journal": "J. Bioenerg. Biomembr.",
"authors": [
"Higgins CF",
"Hyde SC",
"Mimmack MM",
"Gileadi U",
"Gill DR",
"Gallagher MP."
],
"DOI_URL": "http://dx.doi.org/10.1007/BF00762962"
},
"PUB00001137": {
"PMID": 3000770,
"ISBN": null,
"volume": "4",
"issue": "9",
"year": 1985,
"title": "Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems.",
"URL": null,
"raw_pages": "2287-93",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Dassa E",
"Hofnung M."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=3000770"
},
"PUB00003865": {
"PMID": 7934906,
"ISBN": null,
"volume": "12",
"issue": "6",
"year": 1994,
"title": "Bacterial binding protein-dependent permeases: characterization of distinctive signatures for functionally related integral cytoplasmic membrane proteins.",
"URL": null,
"raw_pages": "993-1004",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol. Microbiol.",
"authors": [
"Saurin W",
"Koster W",
"Dassa E."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.1994.tb01087.x"
},
"PUB00003831": {
"PMID": 1738314,
"ISBN": null,
"volume": "6",
"issue": "1",
"year": 1992,
"title": "Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium.",
"URL": null,
"raw_pages": "47-57",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol. Microbiol.",
"authors": [
"Pearce SR",
"Mimmack ML",
"Gallagher MP",
"Gileadi U",
"Hyde SC",
"Higgins CF."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.1992.tb00836.x"
},
"PUB00035343": {
"PMID": 2188958,
"ISBN": null,
"volume": "172",
"issue": "6",
"year": 1990,
"title": "Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster.",
"URL": null,
"raw_pages": "3351-7",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Sirko A",
"Hryniewicz M",
"Hulanicka D",
"Bock A."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=2188958&action=stream&blobtype=pdf"
},
"PUB00035344": {
"PMID": 7608089,
"ISBN": null,
"volume": "177",
"issue": "14",
"year": 1995,
"title": "Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins.",
"URL": null,
"raw_pages": "4134-6",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Sirko A",
"Zatyka M",
"Sadowy E",
"Hulanicka D."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7608089&action=stream&blobtype=pdf"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR035906",
"name": "MetI-like superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 21074,
"pathways": 0,
"proteins": 21070,
"proteomes": 6634,
"sets": 0,
"structural_models": {
"alphafold": 16023,
"bfvd": 0
},
"structures": 0,
"taxa": 11763
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
