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{
"metadata": {
"accession": "IPR005427",
"entry_id": null,
"type": "family",
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"source_database": "interpro",
"member_databases": {
"pfam": {
"PF09599": "Salmonella-Shigella invasin protein C (IpaC_SipC)"
},
"ncbifam": {
"TIGR02101": "IpaC/SipC family type III secretion system effector"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR005427",
"name": "Effector protein BipC/T3SS SctB",
"type": "Family",
"children": []
},
"name": {
"name": "Effector protein BipC/T3SS SctB",
"short": "BipC/SctB"
},
"description": [
{
"text": "<p>Some Gram-negative animal enteropathogens express a specialised secretion system to directly \"inject\" exotoxins into the cytoplasm of host cells. The system is composed of structural proteins and exotoxin effectors; these are often encoded on large virulence plasmids or on the bacterial chromosome itself [[cite:PUB00007817]]. Members may be referred to as invasins, pathogenicity island effectors, and cell invasion proteins [[cite:PUB00007582]].</p>\n\n<p>The Shigella flexneri invasion plasmid antigen (ipa) genes are found on such a plasmid, and are highly regulated [[cite:PUB00007818]]. Homologues of the ipa genes (SipC/SspC) have been found in Salmonella typhimurium [[cite:PUB00007582]], and both pathogens utilise their type III system to translocate their invasive effectors. SipB/SctE1 and SipC/SctB1 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells [[cite:PUB00151516]]. These are responsible for interacting directly with the host eukaryotic cell. IpaC can activate cellular kinase activity once in the host cytoplasm, and thus promotes cellular uptake of S. flexneri [[cite:PUB00007819], [cite:PUB00151514]]. In addition, it has been found that SipC interacts with another Salmonella protein, SipA, to enhance its reorganisation of the host cell actin cytoskeleton, thereby facilitating cellular uptake of the Salmonella bacterium by the eukaryotic cell [[cite:PUB00007819]].</p>",
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"PUB00007817": {
"PMID": 11018143,
"ISBN": null,
"volume": "54",
"issue": null,
"year": 2000,
"title": "Assembly and function of type III secretory systems.",
"URL": null,
"raw_pages": "735-74",
"medline_journal": "Annu Rev Microbiol",
"ISO_journal": "Annu. Rev. Microbiol.",
"authors": [
"Cornelis GR",
"Van Gijsegem F."
],
"DOI_URL": "http://dx.doi.org/10.1146/annurev.micro.54.1.735"
},
"PUB00007818": {
"PMID": 3057506,
"ISBN": null,
"volume": "85",
"issue": "23",
"year": 1988,
"title": "Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri.",
"URL": null,
"raw_pages": "9317-21",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Venkatesan MM",
"Buysse JM",
"Kopecko DJ."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=3057506"
},
"PUB00007582": {
"PMID": 7608068,
"ISBN": null,
"volume": "177",
"issue": "14",
"year": 1995,
"title": "Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells.",
"URL": null,
"raw_pages": "3965-71",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Kaniga K",
"Tucker S",
"Trollinger D",
"Galan JE."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=7608068"
},
"PUB00007819": {
"PMID": 9784535,
"ISBN": null,
"volume": "66",
"issue": "11",
"year": 1998,
"title": "Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins.",
"URL": null,
"raw_pages": "5295-300",
"medline_journal": "Infect Immun",
"ISO_journal": "Infect. Immun.",
"authors": [
"Carlson SA",
"Jones BD."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=9784535&action=stream&blobtype=pdf"
},
"PUB00151514": {
"PMID": 17367391,
"ISBN": null,
"volume": "63",
"issue": "6",
"year": 2007,
"title": "The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.",
"URL": null,
"raw_pages": "1719-30",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol Microbiol",
"authors": [
"Veenendaal AK",
"Hodgkinson JL",
"Schwarzer L",
"Stabat D",
"Zenk SF",
"Blocker AJ."
],
"DOI_URL": "https://doi.org/10.1111/j.1365-2958.2007.05620.x"
},
"PUB00151516": {
"PMID": 23544147,
"ISBN": null,
"volume": "8",
"issue": "3",
"year": 2013,
"title": "SipB-SipC complex is essential for translocon formation.",
"URL": null,
"raw_pages": "e60499",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Myeni SK",
"Wang L",
"Zhou D."
],
"DOI_URL": "https://doi.org/10.1371/journal.pone.0060499"
}
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"bfvd": 0
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"taxa": 520
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"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0052",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0052"
}
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}
