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{
"metadata": {
"accession": "IPR005251",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"hamap": {
"MF_01678": "Putative methylthioribose-1-phosphate isomerase [mtnA]"
},
"ncbifam": {
"TIGR00512": "S-methyl-5-thioribose-1-phosphate isomerase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000649",
"name": "Initiation factor 2B-related",
"type": "Family",
"children": [
{
"accession": "IPR011559",
"name": "Initiation factor 2B alpha/beta/delta",
"type": "Family",
"children": [
{
"accession": "IPR005250",
"name": "Ribose-1,5-bisphosphate isomerase",
"type": "Family",
"children": []
},
{
"accession": "IPR005251",
"name": "Methylthioribose-1-phosphate isomerase",
"type": "Family",
"children": [
{
"accession": "IPR043679",
"name": "5-deoxyribose 1-phosphate isomerase",
"type": "Family",
"children": []
}
]
}
]
}
]
},
"name": {
"name": "Methylthioribose-1-phosphate isomerase",
"short": "IF-M1Pi"
},
"description": [
{
"text": "<p>This family contains proteins designated as 5-methylthioribose-1-phosphate isomerase (MTNA, [ec:5.3.1.23], [[cite:PUB00016716]]). It also contains putative translation initiation factor 2B subunit proteins.</p>\r\n\r\n<p>5-methylthioribose-1-phosphate isomerase (MTNA) participates in the methionine salvage pathway catalysing the isomerisation of 5-methylthioribose-1-phosphate to 5-methylthio ribulose-1-phosphate [[cite:PUB00016714]]. The methionine salvage pathway leads to the synthesis of methionine from methylthioadenosine, the end product of the spermidine and spermine anabolism in many species.</p>\r\n\r\n<p>The delineation of this family is based in part on a discussion and neighbour-joining phylogenetic study [[cite:PUB00004919], [cite:PUB00016925]], of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. The archaeal proteins are related to the common ancestor of eIF-2B alpha, beta, and delta rather then specifically to any one of them, and that designation of particular archaeal members as corresponding to eIF-2B alpha or eIF-2B delta is imprecise. It has been suggested that designating the archaeal proteins as translation initiation factors remains unproven.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00016716": {
"PMID": 14551435,
"ISBN": null,
"volume": "302",
"issue": "5643",
"year": 2003,
"title": "A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.",
"URL": null,
"raw_pages": "286-90",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Ashida H",
"Saito Y",
"Kojima C",
"Kobayashi K",
"Ogasawara N",
"Yokota A."
],
"DOI_URL": "http://dx.doi.org/10.1126/science.1086997"
},
"PUB00004919": {
"PMID": 9520434,
"ISBN": null,
"volume": "95",
"issue": "7",
"year": 1998,
"title": "Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families.",
"URL": null,
"raw_pages": "3726-30",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Kyrpides NC",
"Woese CR."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.95.7.3726"
},
"PUB00016925": {
"PMID": 9419357,
"ISBN": null,
"volume": "95",
"issue": "1",
"year": 1998,
"title": "Universally conserved translation initiation factors.",
"URL": null,
"raw_pages": "224-8",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Kyrpides NC",
"Woese CR."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.95.1.224"
},
"PUB00016714": {
"PMID": 15215245,
"ISBN": null,
"volume": "279",
"issue": "35",
"year": 2004,
"title": "Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits.",
"URL": null,
"raw_pages": "37087-94",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Bumann M",
"Djafarzadeh S",
"Oberholzer AE",
"Bigler P",
"Altmann M",
"Trachsel H",
"Baumann U."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M404458200"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR037171",
"name": "NagB/RpiA transferase-like",
"type": "homologous_superfamily"
},
{
"accession": "IPR027363",
"name": "Methylthioribose-1-phosphate isomerase, N-terminal",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 13495,
"pathways": 14,
"proteins": 13491,
"proteomes": 8995,
"sets": 0,
"structural_models": {
"alphafold": 10720,
"bfvd": 0
},
"structures": 9,
"taxa": 19233
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0729",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0729"
}
]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "5.3.1.23",
"url": "https://enzyme.expasy.org/EC/5.3.1.23"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "1t5o",
"name": "Crystal structure of the translation initiation factor eIF-2B, subunit delta, from A. fulgidus"
}
}
}
