"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR004861"	"{'subfamilies': 0, 'domain_architectures': 87, 'interactions': 0, 'matches': 7101, 'pathways': 0, 'proteins': 6895, 'proteomes': 1974, 'sets': 0, 'structural_models': {'alphafold': 6070, 'bfvd': 1}, 'structures': 17, 'taxa': 4798}"	"{}"	"[{'text': '<p>This group of atypical dual-specificity phosphatases are predominantly from fungi, plants and bacteria. This entry includes budding yeast Siw14 (also known as Oca3) and related proteins. Siw14 is a inositol pyrophosphate phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7 isoform 5PP-IP5to IP6 [[cite:PUB00088170]]. This entry also includes budding yeast Oca1/2/4/6 and Arabidopsis DSP1/2/3/4/5. All DSPs tested (AtPFA-DSP1, -2, -3, and -5) displayed phosphatase activity toward PI(3,5)P2, with AtPFA-DSP2 showing a higher activity [[cite:PUB00088172]]. Oca1/2/4/6 are putative phosphatases associated with the caffeine-sensitivity stress pathway in S. cerevisiae [[cite:PUB00088172]]. It also includes dual specificity protein phosphatase TpbA that regulates diverse phenotypes in P.aeruginosa via regulation of the concentration of cellular c-di-GMP [[cite:PUB00078743]]. This phosphatase acts by dephosphorylating the membrane-anchored diguanylate cyclase TpbB at tyrosine and serine/threonine sites, leading to inactivation of TpbB and reduced c-di-GMP production [[cite:PUB00078743], [cite:PUB00151104]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR004861', 'name': 'Atypical dual-specificity phosphatase Siw14-like', 'type': 'Family', 'children': [{'accession': 'IPR020428', 'name': 'Atypical dual-specificity phosphatase Siw14-like, plant and fungi', 'type': 'Family', 'children': []}]}"	""	False	False	False	"{'PUB00088170': {'PMID': 26828065, 'ISBN': None, 'volume': '291', 'issue': '13', 'year': 2016, 'title': 'A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5).', 'URL': None, 'raw_pages': '6772-83', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Steidle EA', 'Chong LS', 'Wu M', 'Crooke E', 'Fiedler D', 'Resnick AC', 'Rolfes RJ.'], 'DOI_URL': 'https://doi.org/10.1074/jbc.M116.714907'}, 'PUB00088172': {'PMID': 21409566, 'ISBN': None, 'volume': '285', 'issue': '4', 'year': 2011, 'title': 'Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms.', 'URL': None, 'raw_pages': '341-54', 'medline_journal': 'Mol Genet Genomics', 'ISO_journal': 'Mol. Genet. Genomics', 'authors': ['Roma-Mateo C', 'Sacristan-Reviriego A', 'Beresford NJ', 'Caparros-Martin JA', 'Culianez-Macia FA', 'Martin H', 'Molina M', 'Tabernero L', 'Pulido R.'], 'DOI_URL': 'https://doi.org/10.1007/s00438-011-0611-6'}, 'PUB00078743': {'PMID': 19543378, 'ISBN': None, 'volume': '5', 'issue': '6', 'year': 2009, 'title': 'Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).', 'URL': None, 'raw_pages': 'e1000483', 'medline_journal': 'PLoS Pathog', 'ISO_journal': 'PLoS Pathog.', 'authors': ['Ueda A', 'Wood TK.'], 'DOI_URL': 'http://dx.doi.org/10.1371/journal.ppat.1000483'}, 'PUB00151104': {'PMID': 20946878, 'ISBN': None, 'volume': '402', 'issue': '2', 'year': 2010, 'title': 'Tyrosine phosphatase TpbA controls rugose colony formation in Pseudomonas aeruginosa by dephosphorylating diguanylate cyclase TpbB.', 'URL': None, 'raw_pages': '351-5', 'medline_journal': 'Biochem Biophys Res Commun', 'ISO_journal': 'Biochem Biophys Res Commun', 'authors': ['Pu M', 'Wood TK.'], 'DOI_URL': None}}"	"{'pfam': {'PF03162': 'Tyrosine phosphatase family'}}"	"{'name': 'Atypical dual-specificity phosphatase Siw14-like', 'short': 'Siw14-like'}"	"[{'accession': 'IPR029021', 'name': 'Protein-tyrosine phosphatase-like', 'type': 'homologous_superfamily'}]"	"{'accession': '7mod', 'name': 'Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in Complex with Phosphate in Conformation A (Pi(A))'}"	""	"interpro"	"family"	""