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{
    "metadata": {
        "accession": "IPR004308",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0004357",
                "name": "glutamate-cysteine ligase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006750",
                "name": "glutathione biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR11164": "GLUTAMATE CYSTEINE LIGASE"
            },
            "pfam": {
                "PF03074": "Glutamate-cysteine ligase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR004308",
            "name": "Glutamate-cysteine ligase catalytic subunit",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Glutamate-cysteine ligase catalytic subunit",
            "short": "GCS"
        },
        "description": [
            {
                "text": "<p>This family represents the catalytic subunit of glutamate-cysteine ligase ([ec:6.3.2.2]), also known as gamma-glutamylcysteine synthetase (GCS). This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR014746",
                "name": "Glutamine synthetase/guanido kinase, catalytic domain",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 70,
            "interactions": 0,
            "matches": 6279,
            "pathways": 11,
            "proteins": 5656,
            "proteomes": 2891,
            "sets": 0,
            "structural_models": {
                "alphafold": 5126,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 8384
        },
        "entry_annotations": {
            "alignment:seed": 51,
            "alignment:full": 4416
        },
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp1359",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1359"
                    },
                    {
                        "accession": "GenProp0030",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0030"
                    },
                    {
                        "accession": "GenProp1664",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1664"
                    }
                ]
            },
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "6.3.2.2",
                        "url": "https://enzyme.expasy.org/EC/6.3.2.2"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}