"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR003925"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 490, 'pathways': 1, 'proteins': 155, 'proteomes': 119, 'sets': 0, 'structural_models': {'alphafold': 132, 'bfvd': 0}, 'structures': 0, 'taxa': 400}"	"{}"	"[{'text': '<p>Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [[cite:PUB00070981], [cite:PUB00070980], [cite:PUB00070979]]. They can also form heteropolymers with each other within and between tight junction strands [[cite:PUB00070982]]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [[cite:PUB00070979]]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [[cite:PUB00070979]].</p>', 'llm': False, 'checked': False, 'updated': False}, {'text': '<p>Claudin-6 was identified through searching expressed sequence tag (EST)\r\ndatabases for sequences similar to claudin-1 and -2 [[cite:PUB00004927]]. It was subsequently cloned and expressed in cells, where it was shown to concentrate at tight junctions. Human and mouse isoforms have been identified.  Claudin-6 shares ~25-70% overall similarity with other claudin family members at the amino acid level, displaying highest similarity to claudin-9.</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	"[{'identifier': 'GO:0005198', 'name': 'structural molecule activity', 'category': {'code': 'F', 'name': 'molecular_function'}}, {'identifier': 'GO:0005923', 'name': 'bicellular tight junction', 'category': {'code': 'C', 'name': 'cellular_component'}}]"	"{'accession': 'IPR004031', 'name': 'PMP-22/EMP/MP20/Claudin', 'type': 'Family', 'children': [{'accession': 'IPR004032', 'name': 'PMP-22/EMP/MP20', 'type': 'Family', 'children': [{'accession': 'IPR003932', 'name': 'Epithelial membrane protein EMP-1', 'type': 'Family', 'children': []}, {'accession': 'IPR003933', 'name': 'Epithelial membrane protein 2', 'type': 'Family', 'children': []}, {'accession': 'IPR003934', 'name': 'Epithelial membrane protein EMP-3', 'type': 'Family', 'children': []}, {'accession': 'IPR003935', 'name': 'Lens fibre membrane intrinsic protein', 'type': 'Family', 'children': []}, {'accession': 'IPR003936', 'name': 'Peripheral myelin protein PMP22', 'type': 'Family', 'children': []}]}, {'accession': 'IPR006187', 'name': 'Claudin', 'type': 'Family', 'children': [{'accession': 'IPR003548', 'name': 'Claudin-1', 'type': 'Family', 'children': []}, {'accession': 'IPR003549', 'name': 'Claudin-3', 'type': 'Family', 'children': []}, {'accession': 'IPR003550', 'name': 'Claudin-4', 'type': 'Family', 'children': []}, {'accession': 'IPR003551', 'name': 'Claudin-5', 'type': 'Family', 'children': []}, {'accession': 'IPR003552', 'name': 'Claudin-7', 'type': 'Family', 'children': []}, {'accession': 'IPR003553', 'name': 'Claudin-9', 'type': 'Family', 'children': []}, {'accession': 'IPR003554', 'name': 'Claudin-10', 'type': 'Family', 'children': []}, {'accession': 'IPR003555', 'name': 'Claudin-11', 'type': 'Family', 'children': []}, {'accession': 'IPR003925', 'name': 'Claudin-6', 'type': 'Family', 'children': []}, {'accession': 'IPR003927', 'name': 'Claudin-16', 'type': 'Family', 'children': []}, {'accession': 'IPR003928', 'name': 'Claudin-18', 'type': 'Family', 'children': []}, {'accession': 'IPR005411', 'name': 'Claudin-2', 'type': 'Family', 'children': []}, {'accession': 'IPR008094', 'name': 'Claudin-15', 'type': 'Family', 'children': []}]}, {'accession': 'IPR008368', 'name': 'Voltage-dependent calcium channel, gamma subunit', 'type': 'Family', 'children': [{'accession': 'IPR005421', 'name': 'Voltage-dependent calcium channel, gamma-1 subunit', 'type': 'Family', 'children': []}, {'accession': 'IPR005422', 'name': 'Voltage-dependent calcium channel, gamma-2 subunit', 'type': 'Family', 'children': []}, {'accession': 'IPR005423', 'name': 'Voltage-dependent calcium channel, gamma-4 subunit', 'type': 'Family', 'children': []}, {'accession': 'IPR008369', 'name': 'Voltage-dependent calcium channel, gamma-5 subunit', 'type': 'Family', 'children': []}, {'accession': 'IPR008370', 'name': 'Voltage-dependent calcium channel, gamma-6 subunit', 'type': 'Family', 'children': []}, {'accession': 'IPR008371', 'name': 'Voltage-dependent calcium channel, gamma-7 subunit', 'type': 'Family', 'children': []}, {'accession': 'IPR008372', 'name': 'Voltage-dependent calcium channel, gamma-8 subunit', 'type': 'Family', 'children': []}]}, {'accession': 'IPR039625', 'name': 'Transmembrane protein 178A/B', 'type': 'Family', 'children': []}, {'accession': 'IPR039951', 'name': 'Transmembrane protein TMEM114/TMEM235', 'type': 'Family', 'children': []}]}"	""	False	False	False	"{'PUB00070982': {'PMID': 10562289, 'ISBN': None, 'volume': '147', 'issue': '4', 'year': 1999, 'title': 'Manner of interaction of heterogeneous claudin species within and between tight junction strands.', 'URL': None, 'raw_pages': '891-903', 'medline_journal': 'J Cell Biol', 'ISO_journal': 'J. Cell Biol.', 'authors': ['Furuse M', 'Sasaki H', 'Tsukita S.'], 'DOI_URL': 'http://dx.doi.org/10.1083/jcb.147.4.891'}, 'PUB00070980': {'PMID': 20188437, 'ISBN': None, 'volume': '89', 'issue': '7', 'year': 2010, 'title': 'The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility.', 'URL': None, 'raw_pages': '547-56', 'medline_journal': 'Eur J Cell Biol', 'ISO_journal': 'Eur. J. Cell Biol.', 'authors': ['Inai T', 'Kamimura T', 'Hirose E', 'Iida H', 'Shibata Y.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.ejcb.2010.01.003'}, 'PUB00070981': {'PMID': 21372174, 'ISBN': None, 'volume': '22', 'issue': '9', 'year': 2011, 'title': 'Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.', 'URL': None, 'raw_pages': '1495-504', 'medline_journal': 'Mol Biol Cell', 'ISO_journal': 'Mol. Biol. Cell', 'authors': ['Yamazaki Y', 'Tokumasu R', 'Kimura H', 'Tsukita S.'], 'DOI_URL': 'http://dx.doi.org/10.1091/mbc.E10-12-1003'}, 'PUB00004927': {'PMID': 9892664, 'ISBN': None, 'volume': '96', 'issue': '2', 'year': 1999, 'title': 'Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.', 'URL': None, 'raw_pages': '511-6', 'medline_journal': 'Proc Natl Acad Sci U S A', 'ISO_journal': 'Proc. Natl. Acad. Sci. U.S.A.', 'authors': ['Morita K', 'Furuse M', 'Fujimoto K', 'Tsukita S.'], 'DOI_URL': 'http://dx.doi.org/10.1073/pnas.96.2.511'}, 'PUB00070979': {'PMID': 24665401, 'ISBN': None, 'volume': '1', 'issue': '3', 'year': 2013, 'title': 'Claudin interactions in and out of the tight junction.', 'URL': None, 'raw_pages': 'e25247', 'medline_journal': 'Tissue Barriers', 'ISO_journal': 'Tissue Barriers', 'authors': ['Van Itallie CM', 'Anderson JM.'], 'DOI_URL': 'http://dx.doi.org/10.4161/tisb.25247'}}"	"{'prints': {'PR01445': 'CLAUDIN6'}}"	"{'name': 'Claudin-6', 'short': 'Claudin6'}"	""	""	""	"interpro"	"family"	""