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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR003925",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0005198",
"name": "structural molecule activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005923",
"name": "bicellular tight junction",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"prints": {
"PR01445": "CLAUDIN6"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR004031",
"name": "PMP-22/EMP/MP20/Claudin",
"type": "Family",
"children": [
{
"accession": "IPR004032",
"name": "PMP-22/EMP/MP20",
"type": "Family",
"children": [
{
"accession": "IPR003932",
"name": "Epithelial membrane protein EMP-1",
"type": "Family",
"children": []
},
{
"accession": "IPR003933",
"name": "Epithelial membrane protein 2",
"type": "Family",
"children": []
},
{
"accession": "IPR003934",
"name": "Epithelial membrane protein EMP-3",
"type": "Family",
"children": []
},
{
"accession": "IPR003935",
"name": "Lens fibre membrane intrinsic protein",
"type": "Family",
"children": []
},
{
"accession": "IPR003936",
"name": "Peripheral myelin protein PMP22",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR006187",
"name": "Claudin",
"type": "Family",
"children": [
{
"accession": "IPR003548",
"name": "Claudin-1",
"type": "Family",
"children": []
},
{
"accession": "IPR003549",
"name": "Claudin-3",
"type": "Family",
"children": []
},
{
"accession": "IPR003550",
"name": "Claudin-4",
"type": "Family",
"children": []
},
{
"accession": "IPR003551",
"name": "Claudin-5",
"type": "Family",
"children": []
},
{
"accession": "IPR003552",
"name": "Claudin-7",
"type": "Family",
"children": []
},
{
"accession": "IPR003553",
"name": "Claudin-9",
"type": "Family",
"children": []
},
{
"accession": "IPR003554",
"name": "Claudin-10",
"type": "Family",
"children": []
},
{
"accession": "IPR003555",
"name": "Claudin-11",
"type": "Family",
"children": []
},
{
"accession": "IPR003925",
"name": "Claudin-6",
"type": "Family",
"children": []
},
{
"accession": "IPR003927",
"name": "Claudin-16",
"type": "Family",
"children": []
},
{
"accession": "IPR003928",
"name": "Claudin-18",
"type": "Family",
"children": []
},
{
"accession": "IPR005411",
"name": "Claudin-2",
"type": "Family",
"children": []
},
{
"accession": "IPR008094",
"name": "Claudin-15",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR008368",
"name": "Voltage-dependent calcium channel, gamma subunit",
"type": "Family",
"children": [
{
"accession": "IPR005421",
"name": "Voltage-dependent calcium channel, gamma-1 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005422",
"name": "Voltage-dependent calcium channel, gamma-2 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005423",
"name": "Voltage-dependent calcium channel, gamma-4 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008369",
"name": "Voltage-dependent calcium channel, gamma-5 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008370",
"name": "Voltage-dependent calcium channel, gamma-6 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008371",
"name": "Voltage-dependent calcium channel, gamma-7 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008372",
"name": "Voltage-dependent calcium channel, gamma-8 subunit",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR039625",
"name": "Transmembrane protein 178A/B",
"type": "Family",
"children": []
},
{
"accession": "IPR039951",
"name": "Transmembrane protein TMEM114/TMEM235",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Claudin-6",
"short": "Claudin6"
},
"description": [
{
"text": "<p>Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [[cite:PUB00070981], [cite:PUB00070980], [cite:PUB00070979]]. They can also form heteropolymers with each other within and between tight junction strands [[cite:PUB00070982]]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [[cite:PUB00070979]]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [[cite:PUB00070979]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Claudin-6 was identified through searching expressed sequence tag (EST)\r\ndatabases for sequences similar to claudin-1 and -2 [[cite:PUB00004927]]. It was subsequently cloned and expressed in cells, where it was shown to concentrate at tight junctions. Human and mouse isoforms have been identified. Claudin-6 shares ~25-70% overall similarity with other claudin family members at the amino acid level, displaying highest similarity to claudin-9.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00070982": {
"PMID": 10562289,
"ISBN": null,
"volume": "147",
"issue": "4",
"year": 1999,
"title": "Manner of interaction of heterogeneous claudin species within and between tight junction strands.",
"URL": null,
"raw_pages": "891-903",
"medline_journal": "J Cell Biol",
"ISO_journal": "J. Cell Biol.",
"authors": [
"Furuse M",
"Sasaki H",
"Tsukita S."
],
"DOI_URL": "http://dx.doi.org/10.1083/jcb.147.4.891"
},
"PUB00070980": {
"PMID": 20188437,
"ISBN": null,
"volume": "89",
"issue": "7",
"year": 2010,
"title": "The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility.",
"URL": null,
"raw_pages": "547-56",
"medline_journal": "Eur J Cell Biol",
"ISO_journal": "Eur. J. Cell Biol.",
"authors": [
"Inai T",
"Kamimura T",
"Hirose E",
"Iida H",
"Shibata Y."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.ejcb.2010.01.003"
},
"PUB00070981": {
"PMID": 21372174,
"ISBN": null,
"volume": "22",
"issue": "9",
"year": 2011,
"title": "Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.",
"URL": null,
"raw_pages": "1495-504",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol. Biol. Cell",
"authors": [
"Yamazaki Y",
"Tokumasu R",
"Kimura H",
"Tsukita S."
],
"DOI_URL": "http://dx.doi.org/10.1091/mbc.E10-12-1003"
},
"PUB00004927": {
"PMID": 9892664,
"ISBN": null,
"volume": "96",
"issue": "2",
"year": 1999,
"title": "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.",
"URL": null,
"raw_pages": "511-6",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Morita K",
"Furuse M",
"Fujimoto K",
"Tsukita S."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.96.2.511"
},
"PUB00070979": {
"PMID": 24665401,
"ISBN": null,
"volume": "1",
"issue": "3",
"year": 2013,
"title": "Claudin interactions in and out of the tight junction.",
"URL": null,
"raw_pages": "e25247",
"medline_journal": "Tissue Barriers",
"ISO_journal": "Tissue Barriers",
"authors": [
"Van Itallie CM",
"Anderson JM."
],
"DOI_URL": "http://dx.doi.org/10.4161/tisb.25247"
}
},
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"interactions": 0,
"matches": 490,
"pathways": 1,
"proteins": 155,
"proteomes": 119,
"sets": 0,
"structural_models": {
"alphafold": 132,
"bfvd": 0
},
"structures": 0,
"taxa": 400
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
