GET /api/entry/InterPro/IPR003074
HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 91.0
InterPro-Version-Minor: 1
Vary: Accept

{
    "metadata": {
        "accession": "IPR003074",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004879",
                "name": "nuclear receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "prints": {
                "PR01288": "PROXISOMEPAR"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR001723",
            "name": "Nuclear hormone receptor",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR000003",
                    "name": "Retinoid X receptor/HNF4",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR000128",
                    "name": "Progesterone receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR000324",
                    "name": "Vitamin D receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR001409",
                    "name": "Glucocorticoid receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR001728",
                    "name": "Thyroid hormone receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR003069",
                    "name": "Ecdysteroid receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR003070",
                    "name": "Orphan nuclear receptor",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR003071",
                            "name": "Orphan nuclear receptor, HMR type",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003072",
                            "name": "Orphan nuclear receptor, NOR1 type",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003073",
                            "name": "Orphan nuclear receptor, NURR type",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR003074",
                    "name": "Peroxisome proliferator-activated receptor",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR003075",
                            "name": "Peroxisome proliferator-activated receptor, beta",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003076",
                            "name": "Peroxisome proliferator-activated receptor alpha",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR003077",
                            "name": "Peroxisome proliferator-activated receptor gamma",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR003078",
                    "name": "Retinoic acid receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR003079",
                    "name": "Nuclear receptor ROR",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR016355",
                    "name": "Nuclear hormone receptor family 5",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR023257",
                    "name": "Liver X receptor",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR024178",
                    "name": "Estrogen receptor/oestrogen-related receptor",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR001292",
                            "name": "Estrogen receptor",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR027289",
                            "name": "Oestrogen-related receptor",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR028355",
                            "name": "Estrogen receptor beta/gamma",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR033544",
                    "name": "Nuclear receptor subfamily 0 group B member 1/2",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "Peroxisome proliferator-activated receptor",
            "short": "1Cnucl_rcpt"
        },
        "description": [
            "<p>Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands [[cite:PUB00015853]]. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [[cite:PUB00004464], [cite:PUB00006168]]. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.</p>\r\n\r\n<p>NRs are extremely important in medical research, a large number of them being implicated in diseases such as cancer, diabetes, hormone resistance syndromes, etc. While several NRs act as ligand-inducible transcription factors, many do not yet have a defined ligand and are accordingly termed 'orphan' receptors. During the last decade, more than 300 NRs have been described, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.</p>",
            "<p>Peroxisome proliferator-activated receptors (PPAR) are ligand-activated\r\n transcription factors that belong to the nuclear hormone receptor \r\nsuperfamily. Three cDNAs encoding PPARs have been isolated from Xenopus laevis: xPPAR alpha, beta and gamma [[cite:PUB00006299]]. All three xPPARs appear to be activated by both synthetic peroxisome proliferators and naturally occurring fatty acids, suggesting a common mode of action for all members of this subfamily of receptors [[cite:PUB00006299]]. Furthermore, the multiplicity of the receptors suggests the existence of hitherto unknown cellular signalling pathways for xenobiotics and putative endogenous ligands [[cite:PUB00006272]]. </p>\r\n<p>Synonym(s): 1C nuclear receptor</p>"
        ],
        "wikipedia": null,
        "literature": {
            "PUB00004464": {
                "PMID": 7899080,
                "ISBN": null,
                "volume": "23",
                "issue": "4",
                "year": 1995,
                "title": "Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
                "URL": null,
                "raw_pages": "606-11",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "Nishikawa J",
                    "Kitaura M",
                    "Imagawa M",
                    "Nishihara T."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/nar/23.4.606"
            },
            "PUB00006168": {
                "PMID": 8165128,
                "ISBN": null,
                "volume": "22",
                "issue": "7",
                "year": 1994,
                "title": "Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
                "URL": null,
                "raw_pages": "1161-6",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "De Vos P",
                    "Schmitt J",
                    "Verhoeven G",
                    "Stunnenberg HG."
                ],
                "DOI_URL": "http://dx.doi.org/10.1093/nar/22.7.1161"
            },
            "PUB00006299": {
                "PMID": 8274443,
                "ISBN": null,
                "volume": "47",
                "issue": "1-6",
                "year": 1993,
                "title": "Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids.",
                "URL": null,
                "raw_pages": "65-73",
                "medline_journal": "J Steroid Biochem Mol Biol",
                "ISO_journal": "J. Steroid Biochem. Mol. Biol.",
                "authors": [
                    "Krey G",
                    "Keller H",
                    "Mahfoudi A",
                    "Medin J",
                    "Ozato K",
                    "Dreyer C",
                    "Wahli W."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/0960-0760(93)90058-5"
            },
            "PUB00006272": {
                "PMID": 1312391,
                "ISBN": null,
                "volume": "68",
                "issue": "5",
                "year": 1992,
                "title": "Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors.",
                "URL": null,
                "raw_pages": "879-87",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Dreyer C",
                    "Krey G",
                    "Keller H",
                    "Givel F",
                    "Helftenbein G",
                    "Wahli W."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/0092-8674(92)90031-7"
            },
            "PUB00015853": {
                "PMID": 14747695,
                "ISBN": null,
                "volume": "2004",
                "issue": "217",
                "year": 2004,
                "title": "Nuclear receptors: the evolution of diversity.",
                "URL": null,
                "raw_pages": "pe4",
                "medline_journal": "Sci STKE",
                "ISO_journal": "Sci. STKE",
                "authors": [
                    "Schwabe JW",
                    "Teichmann SA."
                ],
                "DOI_URL": "http://dx.doi.org/10.1126/stke.2172004pe4"
            }
        },
        "overlaps_with": [
            {
                "accession": "IPR035500",
                "name": "Nuclear hormone receptor-like domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 20918,
            "pathways": 40,
            "proteins": 3458,
            "proteomes": 602,
            "sets": 0,
            "structural_models": {
                "alphafold": 2667,
                "rosettafold": 0
            },
            "structures": 371,
            "taxa": 2214
        },
        "entry_annotations": {},
        "cross_references": {}
    }
}