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{
    "metadata": {
        "accession": "IPR002833",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0004045",
                "name": "peptidyl-tRNA hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd02430": "PTH2"
            },
            "pfam": {
                "PF01981": "Peptidyl-tRNA hydrolase PTH2"
            },
            "panther": {
                "PTHR12649": "PEPTIDYL-TRNA HYDROLASE 2"
            },
            "ncbifam": {
                "TIGR00283": "aminoacyl-tRNA hydrolase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR002833",
            "name": "Peptidyl-tRNA hydrolase, PTH2",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR034759",
                    "name": "Peptidyl-tRNA hydrolase, archaea",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR042237",
                    "name": "Putative peptidyl-tRNA hydrolase PTRHD1",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "Peptidyl-tRNA hydrolase, PTH2",
            "short": "PTH2"
        },
        "description": [
            {
                "text": "<p>Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation [[cite:PUB00020200]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00020200": {
                "PMID": 12475929,
                "ISBN": null,
                "volume": "99",
                "issue": "26",
                "year": 2002,
                "title": "Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast.",
                "URL": null,
                "raw_pages": "16707-12",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "Rosas-Sandoval G",
                    "Ambrogelly A",
                    "Rinehart J",
                    "Wei D",
                    "Cruz-Vera LR",
                    "Graham DE",
                    "Stetter KO",
                    "Guarneros G",
                    "Soll D."
                ],
                "DOI_URL": "http://dx.doi.org/10.1073/pnas.222659199"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR023476",
                "name": "Peptidyl-tRNA hydrolase II domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 150,
            "interactions": 0,
            "matches": 11916,
            "pathways": 5,
            "proteins": 11856,
            "proteomes": 5692,
            "sets": 0,
            "structural_models": {
                "alphafold": 9989,
                "bfvd": 14
            },
            "structures": 8,
            "taxa": 13504
        },
        "entry_annotations": {
            "alignment:seed": 244,
            "alignment:full": 6718
        },
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "3.1.1.29",
                        "url": "https://enzyme.expasy.org/EC/3.1.1.29"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1xty",
            "name": "Crystal structure of Sulfolobus solfataricus peptidyl-tRNA hydrolase"
        }
    }
}