{"metadata":{"accession":"IPR001727","entry_id":null,"type":"family","go_terms":[{"identifier":"GO:0046873","name":"metal ion transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}}],"source_database":"interpro","member_databases":{"pfam":{"PF01169":"Divalent cation/proton antiporter GDT1"},"panther":{"PTHR12608":"TRANSMEMBRANE PROTEIN HTP-1 RELATED"}},"integrated":null,"hierarchy":{"accession":"IPR001727","name":"GDT1-like","type":"Family","children":[]},"name":{"name":"GDT1-like","short":"GDT1-like"},"description":[{"text":"<p>Budding yeast GDT1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation [[cite:PUB00079030]]. Its human homologue, TMEM165, also a Golgi protein, transports Ca2+ and Mn2+, which are both required for proper protein glycosylation in cells [[cite:PUB00079031], [cite:PUB00152812]]. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation [[cite:PUB00079032]]. In Arabidopsis , this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected mutant 71), and GDT1-like protein 1, chloroplastic. It has been reported to be a putative chloroplast-localized Ca(2+)/H(+) antiporter with critical functions in the regulation of PSII and in chloroplast Ca(2+) and pH homeostasis [[cite:PUB00083225]]. It has also been suggested that it may function in Mn(2+) uptake into thylakoids, ensuring optimal PSII performance [[cite:PUB00083226]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083225":{"PMID":27302341,"ISBN":null,"volume":"9","issue":"8","year":2016,"title":"A Putative Chloroplast-Localized Ca(2+)/H(+) Antiporter CCHA1 Is Involved in Calcium and pH Homeostasis and Required for PSII Function in Arabidopsis.","URL":null,"raw_pages":"1183-96","medline_journal":"Mol Plant","ISO_journal":"Mol Plant","authors":["Wang C","Xu W","Jin H","Zhang T","Lai J","Zhou X","Zhang S","Liu S","Duan X","Wang H","Peng C","Yang C."],"DOI_URL":"http://dx.doi.org/10.1016/j.molp.2016.05.015"},"PUB00083226":{"PMID":27020959,"ISBN":null,"volume":"28","issue":"4","year":2016,"title":"The Evolutionarily Conserved Protein PHOTOSYNTHESIS AFFECTED MUTANT71 Is Required for Efficient Manganese Uptake at the Thylakoid Membrane in Arabidopsis.","URL":null,"raw_pages":"892-910","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Schneider A","Steinberger I","Herdean A","Gandini C","Eisenhut M","Kurz S","Morper A","Hoecker N","Ruhle T","Labs M","Flugge UI","Geimer S","Schmidt SB","Husted S","Weber AP","Spetea C","Leister D."],"DOI_URL":"http://dx.doi.org/10.1105/tpc.15.00812"},"PUB00079032":{"PMID":23569283,"ISBN":null,"volume":"110","issue":"17","year":2013,"title":"Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells.","URL":null,"raw_pages":"6859-64","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Demaegd D","Foulquier F","Colinet AS","Gremillon L","Legrand D","Mariot P","Peiter E","Van Schaftingen E","Matthijs G","Morsomme P."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1219871110"},"PUB00079030":{"PMID":27075443,"ISBN":null,"volume":"6","issue":null,"year":2016,"title":"Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation.","URL":null,"raw_pages":"24282","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Colinet AS","Sengottaiyan P","Deschamps A","Colsoul ML","Thines L","Demaegd D","Duchene MC","Foulquier F","Hols P","Morsomme P."],"DOI_URL":"http://dx.doi.org/10.1038/srep24282"},"PUB00079031":{"PMID":24530912,"ISBN":null,"volume":"445","issue":"2","year":2014,"title":"The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1).","URL":null,"raw_pages":"417-21","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Reinhardt TA","Lippolis JD","Sacco RE."],"DOI_URL":"http://dx.doi.org/10.1016/j.bbrc.2014.02.020"},"PUB00152812":{"PMID":32047108,"ISBN":null,"volume":"295","issue":"12","year":2020,"title":"The human Golgi protein TMEM165 transports calcium and manganese in yeast and bacterial cells.","URL":null,"raw_pages":"3865-3874","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Stribny J","Thines L","Deschamps A","Goffin P","Morsomme P."],"DOI_URL":"https://doi.org/10.1074/jbc.RA119.012249"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":130,"interactions":0,"matches":19540,"pathways":0,"proteins":16155,"proteomes":9134,"sets":0,"structural_models":{"alphafold":12943,"bfvd":0},"structures":0,"taxa":18484},"entry_annotations":{"alignment:seed":537,"alignment:full":15141},"cross_references":{"prositedoc":{"displayName":"PROSITE Doc","description":"PROSITE is a database of protein families and domains.","rank":18,"accessions":[{"accession":"PDOC00934","url":"http://prosite.expasy.org/PDOC00934"}]}},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}