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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR001727",
"entry_id": null,
"type": "family",
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{
"identifier": "GO:0046873",
"name": "metal ion transmembrane transporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
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"source_database": "interpro",
"member_databases": {
"pfam": {
"PF01169": "Divalent cation/proton antiporter GDT1"
},
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"PTHR12608": "TRANSMEMBRANE PROTEIN HTP-1 RELATED"
}
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"name": "GDT1-like",
"type": "Family",
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"name": {
"name": "GDT1-like",
"short": "GDT1-like"
},
"description": [
{
"text": "<p>Budding yeast GDT1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation [[cite:PUB00079030]]. Its human homologue, TMEM165, also a Golgi protein, transports Ca2+ and Mn2+, which are both required for proper protein glycosylation in cells [[cite:PUB00079031], [cite:PUB00152812]]. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation [[cite:PUB00079032]]. In Arabidopsis , this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected mutant 71), and GDT1-like protein 1, chloroplastic. It has been reported to be a putative chloroplast-localized Ca(2+)/H(+) antiporter with critical functions in the regulation of PSII and in chloroplast Ca(2+) and pH homeostasis [[cite:PUB00083225]]. It has also been suggested that it may function in Mn(2+) uptake into thylakoids, ensuring optimal PSII performance [[cite:PUB00083226]].</p>",
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"wikipedia": null,
"literature": {
"PUB00083225": {
"PMID": 27302341,
"ISBN": null,
"volume": "9",
"issue": "8",
"year": 2016,
"title": "A Putative Chloroplast-Localized Ca(2+)/H(+) Antiporter CCHA1 Is Involved in Calcium and pH Homeostasis and Required for PSII Function in Arabidopsis.",
"URL": null,
"raw_pages": "1183-96",
"medline_journal": "Mol Plant",
"ISO_journal": "Mol Plant",
"authors": [
"Wang C",
"Xu W",
"Jin H",
"Zhang T",
"Lai J",
"Zhou X",
"Zhang S",
"Liu S",
"Duan X",
"Wang H",
"Peng C",
"Yang C."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.molp.2016.05.015"
},
"PUB00083226": {
"PMID": 27020959,
"ISBN": null,
"volume": "28",
"issue": "4",
"year": 2016,
"title": "The Evolutionarily Conserved Protein PHOTOSYNTHESIS AFFECTED MUTANT71 Is Required for Efficient Manganese Uptake at the Thylakoid Membrane in Arabidopsis.",
"URL": null,
"raw_pages": "892-910",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Schneider A",
"Steinberger I",
"Herdean A",
"Gandini C",
"Eisenhut M",
"Kurz S",
"Morper A",
"Hoecker N",
"Ruhle T",
"Labs M",
"Flugge UI",
"Geimer S",
"Schmidt SB",
"Husted S",
"Weber AP",
"Spetea C",
"Leister D."
],
"DOI_URL": "http://dx.doi.org/10.1105/tpc.15.00812"
},
"PUB00079032": {
"PMID": 23569283,
"ISBN": null,
"volume": "110",
"issue": "17",
"year": 2013,
"title": "Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells.",
"URL": null,
"raw_pages": "6859-64",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Demaegd D",
"Foulquier F",
"Colinet AS",
"Gremillon L",
"Legrand D",
"Mariot P",
"Peiter E",
"Van Schaftingen E",
"Matthijs G",
"Morsomme P."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.1219871110"
},
"PUB00079030": {
"PMID": 27075443,
"ISBN": null,
"volume": "6",
"issue": null,
"year": 2016,
"title": "Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation.",
"URL": null,
"raw_pages": "24282",
"medline_journal": "Sci Rep",
"ISO_journal": "Sci Rep",
"authors": [
"Colinet AS",
"Sengottaiyan P",
"Deschamps A",
"Colsoul ML",
"Thines L",
"Demaegd D",
"Duchene MC",
"Foulquier F",
"Hols P",
"Morsomme P."
],
"DOI_URL": "http://dx.doi.org/10.1038/srep24282"
},
"PUB00079031": {
"PMID": 24530912,
"ISBN": null,
"volume": "445",
"issue": "2",
"year": 2014,
"title": "The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1).",
"URL": null,
"raw_pages": "417-21",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem. Biophys. Res. Commun.",
"authors": [
"Reinhardt TA",
"Lippolis JD",
"Sacco RE."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.bbrc.2014.02.020"
},
"PUB00152812": {
"PMID": 32047108,
"ISBN": null,
"volume": "295",
"issue": "12",
"year": 2020,
"title": "The human Golgi protein TMEM165 transports calcium and manganese in yeast and bacterial cells.",
"URL": null,
"raw_pages": "3865-3874",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Stribny J",
"Thines L",
"Deschamps A",
"Goffin P",
"Morsomme P."
],
"DOI_URL": "https://doi.org/10.1074/jbc.RA119.012249"
}
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"description": "PROSITE is a database of protein families and domains.",
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"accessions": [
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"accession": "PDOC00934",
"url": "http://prosite.expasy.org/PDOC00934"
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