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{
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},
{
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{
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{
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{
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},
{
"accession": "IPR008112",
"name": "Relaxin receptor",
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{
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"accession": "IPR028336",
"name": "Glucose-dependent insulinotropic receptor",
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"name": "Probable G-protein coupled receptor 82",
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"name": "C-C chemokine receptor type 1-9-like",
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"accession": "IPR000248",
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"text": "<p>The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [[cite:PUB00000131], [cite:PUB00002477], [cite:PUB00004960]].</p>",
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"text": "<p>Adrenocorticotrophin (ACTH), melanocyte-stimulating hormones (MSH) and beta-endorphin are peptide products of pituitary pro-opiomelanocortin. ACTH regulates synthesis and release of glucocorticoids and aldosterone in the adrenal cortex; it also has a trophic action on these cells. ACTH and beta-endorphin are synthesised and released in response to corticotrophin-releasing factor at times of stress (heat, cold, infections, etc.) -their release leads to increased metabolism and analgesia. MSH has a trophic action on melanocytes, and regulates pigment production in fish and amphibia. The ACTH receptor is found in high levels in the adrenal cortex -binding sites are present in lower levels in the CNS. The MSH receptor is expressed in high levels in melanocytes, melanomas and their derived cell lines. Receptors are found in low levels in the CNS. MSH regulates temperature control in the septal region of the brain and releases prolactin from the pituitary.</p>",
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