"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR000833"	"{'subfamilies': 0, 'domain_architectures': 3, 'interactions': 0, 'matches': 582, 'pathways': 0, 'proteins': 582, 'proteomes': 386, 'sets': 0, 'structural_models': {'alphafold': 316, 'bfvd': 0}, 'structures': 7, 'taxa': 589}"	"{}"	"[{'text': '<p>Alpha-amylase inhibitor inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. The inhibitor has no action on plant and microbial alpha amylases.</p>\r\n<p>A crystal structure has been determined for tendamistat, the 74-amino acid inhibitor produced by Streptomyces tendae that targets a wide range of mammalian alpha-amylases [[cite:PUB00027644]]. The binding of tendamistat to alpha-amylase leads to the steric blockage of the active site of the enzyme.  The crystal structure of tendamistat revealed an immunoglobulin-like fold that could potentially adopt multiple conformations. Such molecular flexibility could enable an induced-fit type of binding that would both optimise binding and allow broad target specificity.</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	"[{'identifier': 'GO:0015066', 'name': 'alpha-amylase inhibitor activity', 'category': {'code': 'F', 'name': 'molecular_function'}}]"	"{'accession': 'IPR000833', 'name': 'Alpha-amylase inhibitor', 'type': 'Family', 'children': []}"	""	False	False	False	"{'PUB00027644': {'PMID': 14501112, 'ISBN': None, 'volume': '59', 'issue': 'Pt 10', 'year': 2003, 'title': 'Structure of the alpha-amylase inhibitor tendamistat at 0.93 A.', 'URL': None, 'raw_pages': '1737-43', 'medline_journal': 'Acta Crystallogr D Biol Crystallogr', 'ISO_journal': 'Acta Crystallogr. D Biol. Crystallogr.', 'authors': ['Konig V', 'Vertesy L', 'Schneider TR.'], 'DOI_URL': 'http://dx.doi.org/10.1107/S0907444903015828'}}"	"{'pirsf': {'PIRSF001658': 'Alpha-amylase inhibitor, Streptomyces type'}, 'smart': {'SM00783': 'Alpha amylase inhibitor'}, 'pfam': {'PF01356': 'Alpha amylase inhibitor'}}"	"{'name': 'Alpha-amylase inhibitor', 'short': 'A-amylase_inhib'}"	"[{'accession': 'IPR036379', 'name': 'Alpha-amylase inhibitor superfamily', 'type': 'homologous_superfamily'}]"	"{'accession': '1ok0', 'name': 'Crystal Structure of Tendamistat'}"	""	"interpro"	"family"	""