EC 4.2.3.6 - Trichodiene synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 4.2.3.6

Names

Accepted name:
trichodiene synthase
Other names:
trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase
sesquiterpene cyclase
trichodiene synthetase
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)

Reaction

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0045482
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Hohn, T.M. and Vanmiddlesworth, F.
    Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides.
    Arch. Biochem. Biophys. 251: 756-761 (1986). [PMID: 3800398]
  2. Hohn, T. M., Beremand, P. D.
    Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides.
    Gene 79: 131-138 (1989). [PMID: 2777086]
  3. Rynkiewicz, M. J., Cane, D. E., Christianson, D. W.
    Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
    Proc. Natl. Acad. Sci. U.S.A. 98: 13543-13548 (2001). [PMID: 11698643]

[EC 4.2.3.6 created 1989 as EC 4.1.99.6, transferred 2000 to EC 4.2.3.6]