EC 4.2.2.5 - Chondroitin AC lyase

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ENZYME: 4.2.2.5


ID   4.2.2.5
DE   Chondroitin AC lyase.
AN   Chondroitin AC eliminase.
AN   Chondroitin sulfate lyase.
AN   Chondroitinase.
CA   Eliminative degradation of polysaccharides containing 1,4-beta-D-
CA   hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides
CA   containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
CC   -!- Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less
CC       well on hyaluronate.
CC   -!- In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains
CC       comprise a linkage region, a chain cap and a repeat region.
CC   -!- The repeat region of CS is a repeating disaccharide of glucuronic
CC       acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1-
CC       3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6
CC       of GalNAc and C-2 of GlcA.
CC   -!- GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming
CC       the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of
CC       DS.
CC   -!- Both the concentrations and locations of sulfate-ester substituents
CC       vary with glucosaminoglycan source.
CC   -!- Formerly EC 4.2.99.6.
DR   Q59288    , CSLA_PEDHD ;
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