EC - 2-methylisocitrate dehydratase

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IntEnz Enzyme Nomenclature


Accepted name:
2-methylisocitrate dehydratase
Other name:
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase
Systematic name:
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]



The enzyme from the fungus Yarrowia lipolytica (Saccharomycopsis) does not act on isocitrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047456
CAS Registry Number: 170780-51-5
UniProtKB/Swiss-Prot: (35) [show] [UniProt]


  1. Aoki, H., Uchiyama, H., Umetsu, H., Tabuchi, T.
    Isolation of 2-methylisocitrate dehydratase, a new enzyme serving in the methylcitric acid cycle for propionate metabolism, from Yarrowia lipolytica.
    Biosci. Biotechnol. Biochem. 59: 1825-1828 (1995).
  2. Tabuchi, T., Umetsu, H., Aoki, H., Uchiyama, H.
    Characteristics of 2-methylisocitrate dehydratase, isolated from Yarrowia lipolytica, in comparison to aconitase.
    Biosci. Biotechnol. Biochem. 59: 2013-2017 (1995).

[EC created 1999]