EC 4.2.1.28 - Propanediol dehydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.28

Names

Accepted name:
propanediol dehydratase
Other names:
1,2-propanediol dehydratase
DL-1,2-propanediol hydro-lyase
adenosylcobalamin-dependent diol dehydratase
coenzyme B12-dependent diol dehydrase
diol dehydrase
diol dehydratase
dioldehydratase
meso-2,3-butanediol dehydrase
propanediol dehydrase
propane-1,2-diol hydro-lyase
Systematic name:
propane-1,2-diol hydro-lyase (propanal-forming)

Reaction

Cofactor

Comments:

Two different forms of the enzyme have been described. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme. The cobamide-dependent enzyme has been shown to also dehydrate ethylene glycol to acetaldehyde.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050215
CAS Registry Number: 9026-90-8
UniProtKB/Swiss-Prot:

References

  1. Abeles, R.H. and Lee, H.A., Jr.
    An intramolecular oxidation-reduction requiring a cobamide coenzyme.
    J. Biol. Chem. 236 : 2347-2350 (1961). [PMID: 13680987]
  2. Forage, R.G. and Foster, M.A.
    Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases.
    J. Bacteriol. 149 : 413-419 (1982). [PMID: 7035429]
  3. Lee, H.A. and Abeles, R.H.
    Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme.
    J. Biol. Chem. 238 : 2367-2373 (1963). [PMID: 13929077]
  4. LaMattina, J. W., Keul, N. D., Reitzer, P., Kapoor, S., Galzerani, F., Koch, D. J., Gouvea, I. E., Lanzilotta, W. N.
    1,2-Propanediol Dehydration in Roseburia inulinivorans: STRUCTURAL BASIS FOR SUBSTRATE AND ENANTIOMER SELECTIVITY.
    J. Biol. Chem. 291 : 15515-15526 (2016). [PMID: 27252380]

[EC 4.2.1.28 created 1965]