EC - 2,3-dimethylmalate lyase

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IntEnz Enzyme Nomenclature


Accepted name:
2,3-dimethylmalate lyase
Other names:
2,3-dimethylmalate pyruvate-lyase
(2R,3S)-2,3-dimethylmalate pyruvate-lyase
Systematic name:
(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)



Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC (nicotinate dehydrogenase), EC (6-hydroxynicotinate reductase), EC (enamidase), EC (2-hydroxymethylglutarate dehydrogenase), EC (2-methyleneglutarate mutase), EC (methylitaconate Δ-isomerase) and EC (dimethylmaleate hydratase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047529
CAS Registry Number: 73562-28-4


  1. Pirzer, P., Lill, U. and Eggerer, H.
    Nicotinic acid metabolism. 2,3-Dimethylmalate lyase.
    Hoppe-Seyler's Z. Physiol. Chem. 360: 1693-1702 (1979). [PMID: 527937]
  2. Alhapel, A., Darley, D.J., Wagener, N., Eckel, E., Elsner, N. and Pierik, A.J.
    Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
    Proc. Natl. Acad. Sci. USA 103: 12341-12346 (2006). [PMID: 16894175]

[EC created 1981]