EC - Phloretin hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
phloretin hydrolase
Other names:
lactase-phlorerin hydrolase
C-acylphenol hydrolase
2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase [incorrect]
Systematic name:
phloretin acylhydrolase (phloroglucinol forming)



Also hydrolyses other C-acylated phenols related to phloretin. Isolated from the fungus Aspergillus niger and the bacteria Pantoea agglomerans and Eubacterium ramulus.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050180
CAS Registry Number: 37289-38-6


  1. Chatterjee, A. K., Gibbins, L. N.
    Metabolism of phloridzin by Erwinia herbicola: nature of the degradation products, and the purification and properties of phloretin hydrolase.
    J. Bacteriol. 100 : 594-600 (1969). [PMID: 5354935]
  2. Minamikawa, T., Jayasankar, N. P., Bohm, B. A., Taylor, I. E., Towers, G. H.
    An inducible hydrolase from Aspergillus niger, acting on carbon-carbon bonds, for phlorrhizin and other C-acylated phenols.
    Biochem. J. 116 : 889-897 (1970). [PMID: 5441377]
  3. Schoefer, L., Braune, A., Blaut, M.
    Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme.
    Appl. Environ. Microbiol. 70 : 6131-6137 (2004). [PMID: 15466559]

[EC created 1972]