EC 3.4.22.38 - Cathepsin K

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ENZYME: 3.4.22.38


ID   3.4.22.38
DE   Cathepsin K.
AN   Cathepsin O.
AN   Cathepsin O2.
AN   Cathepsin X.
CA   Broad proteolytic activity. With small-molecule substrates and
CA   inhibitors, the major determinant of specificity is P2, which is
CA   preferably Leu, Met > Phe, and not Arg.
CC   -!- Prominently expressed in mammalian osteoclasts, and believed to play
CC       a role in bone resorption.
CC   -!- Belongs to peptidase family C1.
PR   PROSITE; PDOC00126;
DR   Q5E968    , CATK_BOVIN ;  Q3ZKN1    , CATK_CANLF ;  Q90686    , CATK_CHICK ;
DR   P43235    , CATK_HUMAN ;  P61276    , CATK_MACFA ;  P61277    , CATK_MACMU ;
DR   P55097    , CATK_MOUSE ;  Q9GLE3    , CATK_PIG   ;  P43236    , CATK_RABIT ;
DR   O35186    , CATK_RAT   ;
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