EC 3.2.1.130 - Glycoprotein endo-α-1,2-mannosidase

  IntEnz view ENZYME view

ENZYME: 3.2.1.130


ID   3.2.1.130
DE   Glycoprotein endo-alpha-1,2-mannosidase.
AN   Endo-alpha-D-mannosidase.
CA   GlcMan(9)GlcNAc(2)-[protein] + H(2)O = Man(8)GlcNAc(2)-[protein] (isomer
CA   8A(1,2,3)B(1,2)) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose.
CC   -!- The enzyme catalyzes the hydrolysis of the terminal alpha-D-glucosyl-
CC       (1->3)-D-mannosyl unit from the GlcMan(9)(GlcNAc)(2) oligosaccharide
CC       component of N-glucosylated proteins during their processing in the
CC       Golgi apparatus.
DR   Q5SRI9    , MANEA_HUMAN;  Q6NXH2    , MANEA_MOUSE;  Q5RD93    , MANEA_PONAB;
DR   Q5GF25    , MANEA_RAT  ;  Q6DE40    , MANEA_XENLA;
//