EC - Poly(3-hydroxybutyrate) depolymerase

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IntEnz Enzyme Nomenclature


Accepted name:
poly(3-hydroxybutyrate) depolymerase
Other names:
PHB depolymerase
poly(HA) depolymerase
poly(HASCL) depolymerase
poly[(R)-hydroxyalkanoic acid] depolymerase
poly(3HB) depolymerase
poly[(R)-3-hydroxybutyrate] hydrolase
Systematic name:
poly[(R)-3-hydroxybutanoate] hydrolase



Reaction also occurs with esters of other short-chain-length (C1-C5) hydroxyalkanoic acids (HA). There are two types of polymers: native (intracellular) granules are amorphous and have an intact surface layer; denatured (extracellular) granules either have no surface layer or a damaged surface layer and are partially crystalline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050526


  1. Jendrossek, D.
    Microbial degradation of polyesters.
    Adv. Biochem. Eng. Biotechnol. 71: 293-325 (2001). [PMID: 11217416]
  2. García, B., Olivera, E.R., Miñambres, B., Fernández-Valverde, Cañedo, L.M., Prieto, M.A., García, J.L., Martínez, M. and Luengo, J.M.
    Novel biodegradable aromatic plastics from a bacterial source. Genetic and biochemical studies on a route of the phenylacetyl-CoA catabolon.
    J. Biol. Chem. 274: 29228-29241 (1999). [PMID: 10506180]

[EC created 2001]