EC 2.8.1.2 - 3-mercaptopyruvate sulfurtransferase

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ENZYME: 2.8.1.2


ID   2.8.1.2
DE   3-mercaptopyruvate sulfurtransferase.
CA   3-mercaptopyruvate + reduced thioredoxin = pyruvate + hydrogen sulfide +
CA   oxidized thioredoxin.
CF   Zn(2+).
CC   -!- The enzyme catalyzes a transsulfuration reaction from
CC       3-mercaptopyruvate to an internal cysteine residue.
CC   -!- In the presence of a dithiol such as reduced thioredoxin or
CC       dihydrolipoate, the sulfanyl sulfur is released as hydrogen sulfide.
CC   -!- The enzyme participates in a sulfur relay process that leads to the
CC       2-thiolation of some tRNAs and to protein urmylation by transferring
CC       sulfur between the NFS1 cysteine desulfurase (EC 2.8.1.7) and the
CC       MOCS3 sulfurtransferase (EC 2.8.1.11).
PR   PROSITE; PDOC00322;
DR   O64530    , STR1_ARATH ;  Q24JL3    , STR2_ARATH ;  P58388    , THTM_ECO57 ;
DR   P31142    , THTM_ECOLI ;  P25325    , THTM_HUMAN ;  Q99J99    , THTM_MOUSE ;
DR   Q9I452    , THTM_PSEAE ;  P97532    , THTM_RAT   ;  Q9USJ1    , THTM_SCHPO ;
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