EC 2.7.2.2 - Carbamate kinase

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IntEnz Enzyme Nomenclature
EC 2.7.2.2

Names

Accepted name:
carbamate kinase
Other names:
CKase
carbamoyl phosphokinase
carbamyl phosphokinase
Systematic name:
ATP:carbamate phosphotransferase

Reaction

Comments:

The enzyme catalyses the reversible conversion of carbamoyl phosphate and ADP to ATP and carbamate, which hydrolyses to ammonia and hydrogen carbonate. The physiological role of the enzyme is to generate ATP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008804
CAS Registry Number: 9026-69-1
UniProtKB/Swiss-Prot: (48) [show] [UniProt]

References

  1. Bishop, S.H. and Grisolia, S.
    Crystalline carbamate kinase.
    Biochim. Biophys. Acta 118: 211-215 (1966). [PMID: 4959296]
  2. Davis, R.H.
    Carbamyl phosphate synthesis in Neurospora crassa. I. Preliminary characterization of arginine-specific carbamyl phosphokinase.
    Biochim. Biophys. Acta 107: 44-53 (1965). [PMID: 5857367]
  3. Glasziou, K.T.
    The metabolism of arginine in Serratia marcescens. II. Carbamyladenosine diphosphate phosphoferase.
    Aust. J. Biol. Sci. 9: 253-262 (1956).
  4. Jones, M.E., Spector, L. and Lipmann, F.
    Carbamyl phosphate, the carbamyl donor in enzymatic citrulline synthesis.
    J. Am. Chem. Soc. 77: 819-820 (1955).
  5. Srivenugopal, K.S. and Adiga, P.R.
    Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase).
    J. Biol. Chem. 256: 9532-9541 (1981). [PMID: 6895223]

[EC 2.7.2.2 created 1961, modified 2018]